國家衛生研究院 NHRI:Item 3990099045/8259

NHRI > Center for Neuropsychiatric Research > Hwei-Hisen Chen > Conference Papers/Meeting Abstract > Item 3990099045/8259

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Title:	Betaine facilitates extinction of conditioned place preference by methamphetamine and morphine in rats
Authors:	Lee, MY;Liao, TY;Chang, PC;Chen, ST;Chen, HH
Contributors:	Center for Neuropsychiatric Research
Abstract:	Betaine (trimethylglycine) is a neutral chemical compound found naturally in many plants. Recently, we have found that betaine potentially acts on glycine binding site of NMDA receptor as a partial agonist. NMDA receptor glycine binding site agonist and partial agonists have been reported to accelerate extinction of drug seeking behavior. The present study aimed to determine whether betaine facilitates extinction of methamphetamine (MA) and morphine (MOR) conditioned place preference (CPP). After MA/MOR CPP, rats received betaine (100 mg/kg) or saline immediately after con ﬁ ned extinction, with saline injection in previous MA-paired compartment for 3 days. MA CPP was signiﬁcantly reduced during retest after extinction in rats treated with saline and betaine, but MA priming induced reinstatement in the saline-treated, but not betaine-treated rats. MOR CPP was effectively extinct in betaine- , but not saline-treated rats. The MOR priming did not induce reinstatement in the betaine-treated rats. In addition, after complete extinction, acute betaine treatment 30 min prior to MA/MOR priming injection signiﬁcantly reduced the reinstatement. These results demonstrated that betaine facilitates memory consolidation for extinction of approach behavior to environmental stimuli previously paired with MA/MOR and suppresses MA/MOR-induced reinstatement of CPP behavior, suggesting that betaine is a potential therapeutic agent for MA/MOR addiction.
Date:	2014-08
Relation:	Journal of Neurochemistry. 2014 Aug;130(Suppl. s1):63.
Link to:	http://dx.doi.org/10.1111/jnc.12778
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0022-3042&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000339492800154
Appears in Collections:	[Hwei-Hisen Chen] Conference Papers/Meeting Abstract

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