國家衛生研究院 NHRI:Item 3990099045/8263
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    题名: Diabetes and breast cancer in Taiwanese women: A detection bias?
    作者: Tseng, CH
    贡献者: Division of Environmental Health and Occupational Medicine
    摘要: PURPOSE: To evaluate whether diabetes is a risk factor for breast cancer considering confounders and potential detection examinations. METHODS: National Health Insurance data on 501 747 women without breast cancer were retrieved. Three-year cumulative incidence (2003-2005) and risk ratios (RRs) between diabetic and nondiabetic women were calculated. Potential detection examinations were compared between diabetic and nondiabetic women by chi-square test. Odds ratios (ORs) were estimated by logistic regression for diabetes status/duration with and without adjustment for potential detection examinations and confounders. RESULTS: The crude RR (95% confidence interval [CI]) for all ages, and age groups < 50, 50-64 and ≥ 65 years, was 2.62 (2.31-2.91), 2.69 (2.11-3.44), 1.39 (1.15-1.68) and 1.37 (1.03-1.84), respectively. Patients with diabetes more frequently received potential detection examinations than nondiabetes (17.5% vs. 7.4%, P-value < 0.001). The unadjusted OR (95% CI) for breast cancer for diabetes status (yes vs. no) was 2.63 (2.31-2.98) and was significant for any diabetes duration. The OR for diabetes status was 1.81 (95% CI: 1.59-2.06) after adjustment for potential detection examinations. In models adjusted for potential detection examinations, age, living region, occupation, comorbidities and used medications, OR for diabetes status attenuated to 1.13 (95% CI 0.96-1.32, P-value = 0.14) and none was significant for any diabetes duration. Potential detection examinations were associated with a fivefold to sevenfold higher risk in various models, indicating a strong impact of detection bias. CONCLUSIONS: An association between diabetes and breast cancer is observed, but this can be due to potential detection bias and confounders.
    日期: 2014-10
    關聯: European Journal of Clinical Investigation. 2014 Oct;44(10):910-917.
    Link to: http://dx.doi.org/10.1111/eci.12323
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0014-2972&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000342771500003
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84908666270
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