國家衛生研究院 NHRI:Item 3990099045/8276

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Title:	Nicastrin is required for zebrafish pigment and brain development
Authors:	Chong, SW;Jiang, YJ;Tang, CH;You, MS
Contributors:	Institute of Molecular and Genomic Medicine
Abstract:	Background: Alzheimer's disease (AD) is the most common form of dementia and neuropathologically characterized by the presence of neurofibrillary tangles and the deposition of β-amyloid (Aβ) in neuritic plagues. So far three genes have been identified that, when mutated, cause early onset AD: Amyloid precursor protein (APP), Presenilin-1 (PS1), and Presenilin-2 (PS2). Nicastrin is a transmembrane glycoprotein whose mutation causes a type of familial Alzheimer's disease (FAD). This protein forms gamma-secretase complex with PS1, PS2, APH-1, PEN-2 and catenins, which is involved in proteolytically processing APP to the short AD-associated peptide β-amyloid. Another well-known substrate of gamma-secretase is Notch. It has been shown that mouse Nicastrin deficiency causes neurodegeneration recently.
Date:	2014-07
Relation:	Alzheimer's and Dementia. 2014 Jul;10(4, Suppl.):P786.
Link to:	http://dx.doi.org/10.1016/j.jalz.2014.05.1521
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1552-5260&DestApp=IC2JCR
Appears in Collections:	[Yun-Jin Jiang] Conference Papers/Meeting Abstract

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