國家衛生研究院 NHRI:Item 3990099045/8295
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    題名: Prospect and challenges for the development of multivalent vaccines against hand, foot and mouth diseases
    作者: Liu, CC;Chow, YH;Chong, P;Klein, M
    貢獻者: Division of Vaccine Research and Development
    摘要: Enterovirus 71 (EV71), an emerging neurotropic virus and coxsackieviruses (CV) are the major causative agents of hand, foot and mouth diseases (HFMD). These viruses have become a serious public health threat in the Asia Pacific region. Formalin-inactivated EV71 (FI-EV71) vaccines have been developed, evaluated in human clinical trials and were found to elicit full protection against EV71. Their failure to prevent CVA16 infections could compromise the acceptability of monovalent EV71 vaccines. Bivalent FI-EV71/FI-CVA16 vaccines have been found to elicit strong neutralizing antibody responses against both viruses in animal models but did not protect against CVA6 and CVA10 viral infections in cell culture neutralization assay. In this review, we discuss the critical bottlenecks in the development of multivalent HFMD vaccines, including the selection of vaccine strains, animal models to assess vaccine potency, the definition of end-points for efficacy trials, and the need for improved manufacturing processes to produce affordable vaccines.
    日期: 2014-10
    關聯: Vaccine. 2014 Oct;32(47):6177-6182.
    Link to: http://dx.doi.org/10.1016/j.vaccine.2014.08.064
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0264-410X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000344211400001
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84907974648
    顯示於類別:[莊再成] 期刊論文
    [周彥宏] 期刊論文
    [劉家齊] 期刊論文

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