國家衛生研究院 NHRI:Item 3990099045/8302
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    题名: Resveratrol enhanced FOXO3 phosphorylation via synergetic activation of SIRT1 and PI3K/Akt signaling to improve the effects of exercise in elderly rat hearts
    作者: Lin, CH;Lin, CC;Ting, WJ;Pai, PY;Kuo, CH;Ho, TJ;Kuo, WW;Chang, CH;Huang, CY;Lin, WT
    贡献者: Institute of Cellular and Systems Medicine
    摘要: Exercise training is considered a benefit to heart function, but the benefit in aging hearts remains unknown. Activation of the PI3K-Akt survival pathway and suppression of Fas/FADD/caspase-8 apoptotic signaling by exercise training in hearts from young subjects have been described in our previous studies. However, the mechanisms are still unclear and need to be explored in aging hearts. Thus, 18-month-old rats were used as a model and underwent swimming exercise training, resveratrol treatment (15 mg/kg/day), or exercise training with resveratrol treatment for 1 month. The results showed that heart function in each group improved. However, the 18-month-old rats in the exercise-only group experienced the slightly inevitable impact of increased TNF-α, cell apoptosis, and fibrosis. In the protein analysis, the PI3K-Akt pathway was slightly increased with exercise training and resveratrol treatment, but Sirtuin 1 (SIRT1) was only highly activated with resveratrol treatment in the aged rat hearts. Moreover, the exercise training plus resveratrol group benefited from SIRT1 and PI3K-Akt dual pathways and blocked FOXO3 accumulation. Our experimental results strongly suggest that resveratrol treatment improves the beneficial effects of exercise training in aging rat hearts.
    日期: 2014-08-27
    關聯: AGE. 2014 Aug 27;36(5):Article number 9705.
    Link to: http://dx.doi.org/10.1007/s11357-014-9705-5
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000343801300007
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84906462901
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