國家衛生研究院 NHRI:Item 3990099045/8318
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    題名: miR326 maturation is crucial for VEGF-C-driven cortactin expression and esophageal cancer progression
    作者: Hong, CC;Chen, PS;Chiou, J;Chiu, CF;Yang, CY;Hsiao, M;Chang, YW;Yu, YH;Hung, MC;Hsu, NW;Shiah, SG;Hsu, NY;Su, JL
    貢獻者: National Institute of Cancer Research
    摘要: Esophageal cancer is an aggressive human malignancy with rising incidence in the developed world. The vascular endothelial growth factor VEGF-C makes crucial contributions to esophageal cancer progression that are not well understood. Here we report the discovery of regulatory relationship in esophageal cancers between the expression of VEGF-C and cortactin (CTTN), a regulator of the cortical actin cytoskeleton. Upregulation of CTTN expression by VEGF-C enhanced the invasive propertis of esophageal squamous cell carcinoma (ESCC) in vitro and tumor metastasis in vivo. Mechanistic investigations showed that VEGF-C increased CTTN expression by downregulating Dicer-mediated maturation of miR-326, thereby relieving the suppressive effect of miR-326 on CTTN expression. Clinically, expression of Dicer and miR-326 correlated with poor prognosis in esophageal cancer patients. Our findings offer insights into how VEGF-C enhances the robust invasive and metastatic properties of esophageal cancer, which potential implications for the development of new biomarkers or therapies in this setting.
    日期: 2014-11
    關聯: Cancer Research. 2014 Nov;74(21):6280-6290.
    Link to: http://dx.doi.org/10.1158/0008-5472.can-14-0524
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0008-5472&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000344756800033
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84909594668
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