國家衛生研究院 NHRI:Item 3990099045/8340
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12145/12927 (94%)
造訪人次 : 914324      線上人數 : 1366
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/8340


    題名: Troglitazone and delta2troglitazone enhance adiponectin expression in monocytes/macrophages through the AMP-activated protein kinase pathway
    其他題名: Troglitazone and Δ2Troglitazone enhance adiponectin expression in monocytes/macrophages through the AMP-activated protein kinase pathway
    作者: Tsai, JS;Chuang, LM;Chen, CS;Liang, CJ;Chen, YL;Chen, CY
    貢獻者: Division of Geriatric Research
    摘要: Accumulating evidence indicates that the regimen to increase adiponectin will provide a novel therapeutic strategy for inflammation and cardiovascular disorders. Here, we tested the effect of troglitazone (TG) and its newly synthesized derivative, 5-[4-(6-hydroxy-2,5,7,8-tetramethyl-chroman-2-yl-methoxy)-benzylidene]-2,4-thiazo lidinedione (Delta2troglitazone, (Delta2TG)), on the adiponectin expression in monocytes/macrophages and the relative mechanisms. The expression of adiponectin was located in macrophages of atherosclerotic lesions from patients and cholesterol-fed rabbits. TG and Delta2TG enhanced adiponectin mRNA and protein expression in THP-1 cells by quantitative real-time PCR, Western blot, and immunocytochemistry. TG induced adiponectin mRNA expression through a PPARgamma-dependent pathway whereas Delta2TG enhanced adiponectin mRNA expression through a PPARgamma-independent pathway in THP-1 cells. Both TG and Delta2TG enhanced adiponectin mRNA expression through AMP-activated protein kinase (AMPK) activation. TG and Delta2TG decreased the adhesion of THP-1 cells to TNF-alpha-treated HUVECs and the inhibitory effect was abolished by specific antiadiponectin antibodies. TG- and Delta2TG-induced suppression on monocyte adhesion were inhibited by a selective AMPK inhibitor compound C. Our data suggest that the inhibitory effect of TG and Delta2TG on monocyte adhesion might be at least in part through de novo adiponectin expression and activation of an AMPK-dependent pathway, which might play an important role in anti-inflammation and antiatherosclerosis.
    日期: 2014-09-22
    關聯: Mediators of Inflammation. 2014 Sep 22;2014:Article number 726068.
    Link to: http://dx.doi.org/10.1155/2014/726068
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0962-9351&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000344673000001
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84912051927
    顯示於類別:[陳慶餘(2006-2010)] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    PUB25328285.pdf3149KbAdobe PDF535檢視/開啟


    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋