國家衛生研究院 NHRI:Item 3990099045/8344

NHRI > National Institute of Infectious Diseases and Vaccinology > Joe Yen-Hung Chow > Periodical Articles > Item 3990099045/8344

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/8344

Title:	Review of enterovirus 71 vaccines
Authors:	Chong, P;Liu, CC;Chow, YH;Chou, AH;Klein, M
Contributors:	Division of Vaccine Research and Development
Abstract:	Enterovirus 71 (EV71) and coxsackieviruses (CV) are the major causative agents of hand, foot and mouth diseases (HFMD) outbreaks worldwide and have a significant socioeconomic impact in particular in Asia. Formalin-inactivated EV71 (FI-EV71) vaccines evaluated in human clinical trials in China, Taiwan and Singapore were found to be safe and to elicit strong neutralizing antibody responses against EV71 currently circulating in Asia. The results from 3 different phase III clinical trials performed in young children (6 to 60 months) indicate that the efficacy of FI-EV71 vaccines is >90% against EV71-related HFMD and >80% against EV71-associated serious diseases, but the vaccines did not protect against CVA16 infections. Here we discuss the critical factors affecting EV71 vaccine product registration, including clinical epidemiology, antigenic shift issues in cross-protection and vaccine strain selection, standardized animal models for potency test, and cost-effective manufacturing processes for potential incorporation of FI-EV71 vaccine into EPI vaccines.
Date:	2015-03
Relation:	Clinical Infectious Diseases. 2015 Mar;60(5):797-803.
Link to:	http://dx.doi.org/10.1093/cid/ciu852
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1058-4838&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000349766100021
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84935425287
Appears in Collections:	[Joe Yen-Hung Chow] Periodical Articles [Chia-Chyi Liu] Periodical Articles [Pele Choi-Sing Chong] Periodical Articles

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