國家衛生研究院 NHRI:Item 3990099045/8444
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 12145/12927 (94%)
造访人次 : 855256      在线人数 : 1038
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于NHRI ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/8444


    题名: Chemical constituents and cytotoxic activities from the root and the stem of Reevesia formosana
    作者: Chang, HS;Peng, HT;Lee, SJ;Lin, CH;Chen, IS
    贡献者: Institute of Biotechnology and Pharmaceutical Research
    摘要: In our previous studies, we have reported 13 new cardenolide glycosides with potent cytotoxicities, reevesiosides A-I and epi-reevesiosides F-I from the root of Reevesia formosana (Sterculiaceae). Continuing investigation of the root and the stem of this species led to the isolation of three new lignanoids, reevesic acid, reevesilignan, and reevesiacoumarin, two new sesquiterpenes, reevesiterpenol A and reevesiterpenol B, one new triterpene, 3α,27-di-O-caffeoylbetulinic acid, along with 37 known compounds including nine lignanoids, eight triterpenes, six steroids, four sesquiterpenes, three coumarins, three cardenolide glycosides, two benzenoids, one proanthocyanidin, and Q10. Three additional known cardenolide glycosides, strophathojavoside, strophalloside, and ascleposide isolated from the root of this plant also displayed potent cytotoxicity against the MCF-7, NCI-H460, and Hep G2 cancer cell lines, with IC50 values of 0.767 ± 0.031, 0.175 ± 0.011, and 0.649 ± 0.06; 3.456± 0.130, 0.62 ± 0.059, and 2.593 ± 0.132; 0.166 ± 0.015, 0.037 ± 0.002, and 0.374 ± 0.020µM, respectively. The new triterpene, 3α,27-di-O-caffeoylbetulinic acid isolated from the stem of this species showed a moderate cytotoxicity against NCI-H460 cancer cell line. The structures of these compounds were elucidated by spectroscopic techniques.
    日期: 2014-11
    關聯: Planta Medica. 2014 Nov;80(16):1541.
    Link to: https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0034-1395065
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0032-0943&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000345550400591
    显示于类别:[李秀珠] 會議論文/會議摘要

    文件中的档案:

    没有与此文件相关的档案.



    在NHRI中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈