國家衛生研究院 NHRI:Item 3990099045/8448
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12145/12927 (94%)
造訪人次 : 925013      線上人數 : 944
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/8448


    題名: Obesity paradox among type 2 diabetes: Link between obesity and chronic kidney disease
    作者: Chung, HF;Huang, MC;Long, KZ;Hsu, CC;Mamun, AA
    貢獻者: Division of Health Services and Preventive Medicine
    摘要: Background: Obesity has been linked to chronic kidney disease (CKD) in the general population, but little is known about the association of obesity and changes in obesity status with CKD in the diabetic population. Methods: A cohort of 1199 Taiwanese adults with type 2 diabetes was followed up from baseline (2003–2005) to 2010. We evaluated BMI at baseline and repeated in 2008, 2009, and 2010 as a continuous term and a category according to the World Health Organisation (WHO) cut-off points for Asian populations (normal: <23; overweight: 23.0–27.4; obese: ≥27.5 kg/m2). Relative changes in BMI between baseline and 2010 were evaluated as a continuous variable in percentage (%) and a category (<−5, ±5, >+5 to +10, and >+10%). CKD was defined as estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m2 in each time point. We used generalized estimating equation models for repeated measure BMI and CKD, and logistic regression models for changes in BMI and CKD outcomes in 2010. Results: At baseline, 49.4% of subjects were overweight and 29.6% were obese. After a 7-year follow-up, the overall prevalence remained similar in 2010, but over 40% of subjects had a BMI change greater than ±5%. We found higher BMI levels (OR = 1.05, p = 0.018) and greater changes in BMI (OR = 1.06, p < 0.001) to be positively associated with CKD. The multivariate-adjusted OR for CKD was 1.33 (95% CI = 0.95–1.86, p = 0.102) for overweight category and 1.67 (95% CI = 1.11–2.51, p = 0.013) for obese category compared with normal BMI category. Subjects who had a BMI increase >10% had a significant increased risk for CKD (OR = 2.79, 95% CI = 1.49–5.21, p = 0.001) compared with those who remained within a ±5% range of their baseline BMI. Conclusions: In this large cohort of type 2 diabetes, patients who had a high BMI or gained weight over a 7-years follow-up period had a significant increased risk of CKD.
    日期: 2014-12
    關聯: Obesity Research and Clinical Practice. 2014 Dec;8, Supplement 1(Suppl. 1):18-19.
    Link to: http://dx.doi.org/10.1016/j.orcp.2014.10.033
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1871-403X&DestApp=IC2JCR
    顯示於類別:[許志成] 會議論文/會議摘要

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    SDO1871403X14005791.pdf61KbAdobe PDF481檢視/開啟


    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋