國家衛生研究院 NHRI:Item 3990099045/8450
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    题名: H3K9 histone methyltransferase, KMT1E/SETDB1, cooperates with the SMAD2/3 pathway to suppress lung cancer metastasis
    作者: Wu, PC;Lu, JW;Yang, JY;Lin, IH;Ou, DL;Lin, YH;Chou, KH;Huang, WF;Wang, WP;Huang, YL;Hsu, C;Lin, LI;Lin, YM;James Shen, CK;Tzeng, TY
    贡献者: Institute of Cellular and Systems Medicine
    摘要: Aberrant histone methylation is a frequent event during tumor development and progression. KMT1E (also known as SETDB1) is a histone H3K9 methyltransferase that contributes to epigenetic silencing of both oncogenes and tumor suppressor genes in cancer cells. In this report, we demonstrate that KMT1E acts as a metastasis suppressor that is strongly downregulated in highly metastatic lung cancer cells. Restoring KMT1E expression in this setting suppressed filopodia formation, migration, and invasive behavior. Conversely, loss of KMT1E in lung cancer cells with limited metastatic potential promoted migration in vitro and restored metastatic prowess in vivo. Mechanistic investigations indicated that KMT1E cooperates with the TGFβ-regulated complex SMAD2/3 to repress metastasis through ANXA2. Together, our findings defined an essential role for the KMT1E/SMAD2/3 repressor complex in TGFβ-mediated lung cancer metastasis.
    日期: 2014-12-15
    關聯: Cancer Research. 2014 Dec 15;74(24):7333-7343.
    Link to: http://dx.doi.org/10.1158/0008-5472.CAN-13-3572
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0008-5472&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000346363900019
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84918513875
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