國家衛生研究院 NHRI:Item 3990099045/8452
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    题名: Protein kinase C-delta and -beta coordinate flow-induced directionality and deformation of migratory human blood T-lymphocytes
    其它题名: Protein kinase C-δ and -β coordinate flow-induced directionality and deformation of migratory human blood T-lymphocytes
    作者: Wei, SY;Lin, TE;Wang, WL;Lee, PL;Tsai, MC;Chiu, JJ
    贡献者: Institute of Cellular and Systems Medicine
    摘要: T-lymphocyte migration under flow is critical for immune responses, but the mechanisms by which flow modulates the migratory behaviors of T-lymphocytes remain unclear. Human peripheral blood T-lymphocytes (PBTLs), when stimulated with phorbol 12-myristate 13-acetate (PMA), stretched their cell bodies dramatically and moved along the flow direction. In contrast, stromal cell-derived factor-1alpha-stimulated PBTLs deformed and migrated in a random manner. Here we elucidated the molecular mechanisms underlying flow-induced directionality and deformation of PMA-stimulated PBTLs. PMA primed PBTLs for polarization under flow, with protein kinase C (PKC)-delta enriched in the leading edge, PKC-betaI in the microtubule organizing center, and PKC-betaII in the uropod and peripheral region. PKC-delta regulated cell protrusions in the leading edge through Tiam1/Rac1/calmodulin, whereas PKC-beta regulated RhoA/Rho-associated kinase activity and microtubule stability to modulate uropod contractility and detachment. Our findings indicate that PKC-delta and -beta coordinate in the cell leading edge and uropod, respectively, to modulate the directionality and deformability of migratory T-lymphocytes under flow.
    日期: 2014-12
    關聯: Journal of Molecular Cell Biology. 2014 Dec;6(6):458-472.
    Link to: http://dx.doi.org/10.1093/jmcb/mju050
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1674-2788&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000348600100003
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84922434068
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