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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/8459


    Title: Interaction of DRD2TaqI, COMT, and ALDH2 genes associated with bipolar II disorder comorbid with anxiety disorders in Han Chinese in Taiwan
    Authors: Hu, MC;Lee, SY;Wang, TY;Chang, YH;Chen, SL;Chen, SH;Chu, CH;Wang, CL;Lee, IH;Chen, PS;Yang, YK;Lu, RB
    Contributors: Center for Neuropsychiatric Research
    Abstract: It is hypothesized that dopaminergic genes-dopamine type-2 receptor (DRD2), aldehyde dehydrogenase 2 (ALDH2), and catechol-O-methyltransferase (COMT)-are associated with bipolar disorder (BP) and anxiety disorder (AD). Bipolar II (BP-II) is reported to be highly comorbid with AD. We examined whether interactions among these three genes are susceptibility factors in BP-II with AD (BP-II+AD) and without AD (BP-II-AD). In this study, we hypothesize that the interaction of the dopaminergic genes between BP-II+AD and BP-II-AD is significant different. We recruited 1260 participants: 495 with BP-II-AD, 170 with BP-II+AD, and 595 healthy controls without BP-II or AD. Genotyping was done using polymerase chain reactions plus restriction fragment length polymorphism analysis. Genotypic frequencies of the DRD2TaqIA, COMT, and ALDH2 polymorphisms between the two BP-II groups were nonsignificant. In logistic regression, the ALDH2 and DRD2TaqIA genes showed a main effect that was protective against BP-II-AD (odds ratio [OR] = 0.497, p = 0.010, and OR = 0.415, p = 0.017, respectively). The interaction of DRD2TaqIA A1/A1 and ALDH2*1/*1 had a significant risk effect on the BP-II-AD group (OR = 7.177, p < 0.001). However, the interaction of DRD2TaqIA A1/A1, ALDH2*1/*1, and COMTMet/Met&Val/Met become a weak protective factor against BP-II-AD (OR = 0.205, p = 0.047). All of the significant results described above are found only in BP-II-AD. This study supports the hypothesis the interaction of the dopaminergic genes between BP-II+AD and BP-II-AD is significant different,, and provides additional evidence that the DRD2TaqIA A1/A1, ALDH2*1/*1 and COMT genes interact in BP-II-AD but not in BP-II+AD.
    Date: 2015-06
    Relation: Metabolic Brain Disease. 2015 Jun;30(3):755-765.
    Link to: http://dx.doi.org/10.1007/s11011-014-9637-x
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0885-7490&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000353821000017
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84939955064
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