國家衛生研究院 NHRI:Item 3990099045/8464

NHRI > Center for Neuropsychiatric Research > Hwei-Hisen Chen > Periodical Articles > Item 3990099045/8464

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/8464

Title:	Three arginine-rich cell-penetrating peptides facilitate cellular internalization of red-emitting quantum dots
Authors:	Liu, BR;Chen, HH;Chan, MH;Huang, YW;Aronstam, RS;Lee, HJ
Contributors:	Center for Neuropsychiatric Research
Abstract:	Nanoparticles, such as semiconductor quantum dots (QDs), have been found increasing use in biomedical diagnosis and therapeutics because of their unique properties, including quantum confinement, surface plasmon resonance, and superparamagnetism. Cell-penetrating peptides (CPPs) represent an efficient mechanism to overcome plasma membrane barriers and deliver biologically active molecules into cells. In this study, we demonstrate that three arginine-rich CPPs (SR9, HR9, and PR9) can noncovalently complex with red light emitting QDs, dramatically increasing their delivery into living cells. Zeta-potential and size analyses highlight the importance of electrostatic interactions between positive-charged CPP/QD complexes and negative-charged plasma membranes indicating the efficiency of transmembrane complex transport. Subcellular colocalization indicates associations of QD with early endosomes and lysosomes following PR9-mediated delivery. Our study demonstrates that nontoxic CPPs of varied composition provide an effective vehicle for the design of optimized drug delivery systems.
Date:	2015-03
Relation:	Journal of Nanoscience and Nanotechnology. 2015 Mar;15(3):2067-2078.
Link to:	http://dx.doi.org/10.1166/jnn.2015.9148
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000345054200019
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84920818895
Appears in Collections:	[Hwei-Hisen Chen] Periodical Articles

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