國家衛生研究院 NHRI:Item 3990099045/8482
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/8482


    Title: Turmeric improves post-prandial working memory in pre-diabetes independent of insulin
    Other Titles: 薑黃改善糖尿病前期患者餐後工作記憶之代謝研究
    Authors: Lee, MS;Wahlqvist, ML;Chou, YC;Fang, WH;Lee, JT;Kuan, JC;Liu, HY;Lu, TM;Xiu, L;Hsu, CC;Andrews, ZB;Pan, WH
    Contributors: Division of Health Services and Preventive Medicine
    Abstract: BACKGROUND AND OBJECTIVES: Cognitive impairment develops with pre-diabetes and dementia is a complication of diabetes. Natural products like turmeric and cinnamon may ameliorate the underlying pathogenesis. METHODS: People >=60 years (n=48) with newly-recognised untreated pre-diabetes were randomised to a double-blind metabolic study of placebo, turmeric (1 g), cinnamon (2 g) or both (1 g & 2 g respectively), ingested at a white bread (119 g) breakfast. Observations were made over 6 hours for pre- and post-working memory (WM), glycaemic and insulin responses and biomarkers of Alzheimer's disease (AD)(0, 2, 4 and 6 hours): amyloid precursor protein (APP), gamma-secretase subunits presenilin-1 (PS1), presenilin-2 (PS2), and glycogen synthase kinase (GSK-3beta). Differences between natural product users and non-users were determined by Students t and chi square tests; and between pre-test and post-test WM by Wilcoxon signed rank tests. Interaction between turmeric and cinnamon was tested by 2-way ANOVA. Multivariable linear regression (MLR) took account of BMI, glycaemia, insulin and AD biomarkers in the WM responses to turmeric and cinnamon. RESULTS: No interaction between turmeric and cinnamon was detected. WM increased from 2.6 to 2.9 out of 3.0 (p=0.05) with turmeric, but was unchanged with cinnamon. WM improvement was inversely associated with insulin resistance (r=-0.418, p<0.01), but not with AD biomarkers. With MLR, the WM responses to turmeric were best predicted with an R2 of 34.5%; and with significant turmeric, BMI and insulin/glucose AUC beta-coefficients. CONCLUSIONS: Co-ingestion of turmeric with white bread increases working memory independent of body fatness, glycaemia, insulin, or AD biomarkers. Publisher: Abstract available from the publisher. chi
    Date: 2014-12
    Relation: Asia Pacific Journal of Clinical Nutrition. 2014 Dec;23(4):581-591.
    Link to: http://dx.doi.org/10.6133/apjcn.2014.23.4.24
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0964-7058&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000347143600010
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84925546659
    Appears in Collections:[Wen-Harn Pan] Periodical Articles
    [Chih-Cheng Hsu] Periodical Articles
    [MARK LAWRENCE WAHLQVIST(2008-2012)] Periodical Articles

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