國家衛生研究院 NHRI:Item 3990099045/8516
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    题名: Molecular epidemiology of tuberculosis in Kaohsiung city located at southern Taiwan, 2000-2008
    作者: Chen, YY;Chang, JR;Kuo, SC;Tseng, FC;Huang, WC;Huang, TS;Chen, YS;Chiueh, TS;Sun, JR;Su, IJ;Dou, HY
    贡献者: Division of Infectious Diseases
    摘要: Background: We present the first comprehensive analysis of Mycobacterium tuberculosis (MTB) isolates circulating in southern Taiwan. In this 9-year population-based study, the TB situation in the Kaohsiung region was characterized by genotypic analysis of 421 MTB isolates. Methods: All 421 isolates of MTB were analyzed by spoligotyping and MIRU-VNTR typing. Drug-resistance patterns were also analyzed. Results: The percentage of EAI (East African-Indian) strains increased across sampling years (2000–2008) in southern Taiwan, whereas the proportion of Beijing lineages remained unchanged. Clustering was more frequent with EAI genotype infections (odds ratio = 3.6, p<0.0001) when compared to Beijing genotypes. Notably, MTB resistance to streptomycin (STR) had significantly increased over time, but resistance to other antibiotics, including multidrug resistance, had not. Three major genes (gidB, rpsL and rrs) implicated in STR resistance were sequenced and specific mutations identified. Conclusions: This study revealed that EAI strains were highly transmissible and that STR resistance has increased between 2000 and 2008 in Kaohsiung, Taiwan.
    日期: 2015-01-28
    關聯: PLoS ONE. 2015 Jan 28;10(1):Article number e0117061.
    Link to: http://dx.doi.org/10.1371/journal.pone.0117061
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1932-6203&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000348732100061
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84961288610
    显示于类别:[杜鴻運] 期刊論文
    [蘇益仁(2002-2015)] 期刊論文
    [曾凡真] 期刊論文
    [郭書辰] 期刊論文

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