國家衛生研究院 NHRI:Item 3990099045/8554
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    题名: Screening and profiling stilbene-type natural products with angiotensin-converting enzyme inhibitory activity from Ampelopsis brevipedunculata var. hancei (Planch.) Rehder
    作者: Su, PS;Doerksen, RJ;Chen, SH;Sung, WC;Juan, CC;Rawendra, RDS;Chen, CR;Li, JW;Aisha;Huang, TC;Liao, MH;Chang, CI;Hsu, JL
    贡献者: Division of Vaccine Research and Development
    摘要: In this study, we screened 10 resveratrol derivatives isolated from Ampelopsis brevipedunculata var. hancei (Planch.) Rehder (ABH) for angiotensin I converting enzyme (ACE) inhibitory (ACEI) activity. Among these compounds, (+)-hopeaphenol and (+)-vitisin A showed the lowest IC50 values (?1.5 μM) toward ACE. In addition, the compounds’ abundances and distributions in ABH were profiled using liquid chromatography–tandem mass spectrometry (LC–MS/MS). Interestingly, trimers and tetramers of resveratrol were mainly obtained from the bark of ABH when 90% ethanol was used for extraction. This result implies that the antihypertension effect of ABH extract may be mainly contributed by (+)-hopeaphenol (F1) and (+)-vitisin A (F2) in the ABH bark due to their remarkable ACE inhibitions. Moreover, the sizes and structures of these compounds were further correlated to their affinities toward ACE using molecular docking calculations. The results showed that resveratrol tetramers interact with ACE more favorably than other smaller oligomers.
    日期: 2015-04-10
    關聯: Journal of Pharmaceutical and Biomedical Analysis. 2015 Apr 10;108:70-77.
    Link to: http://dx.doi.org/10.1016/j.jpba.2015.01.053
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0731-7085&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000385991600009
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84923112445
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