國家衛生研究院 NHRI:Item 3990099045/8612
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    題名: The antimicrobial susceptibility and impact of ESBL-carrying Enterobacteriaceae in nursing home in Taiwan
    作者: Liu, HC;Hung, YP;Lin, HJ;Liu, HC;Lee, JC;Li, CW;Wu, YH;Li, MC;Ko, WC
    貢獻者: Division of Infectious Diseases
    摘要: Purpose: In this study we aim to study antimicrobial susceptibility of clinical E. coli, K. pneumoniae, or P. mirabilis isolates in hospitalized patients with community-onset infections, in order to guide clinicians to select appropriate empirical antibiotics.Material and methods: A retrospective study was performed at medical wards of a district hospital at southern Taiwan between July 2009 and June 2011. Patients were included if they were more than 18 year-old, admitted via the emergent department, and their blood, sputum or urine culture revealed the growth of E. coli, K. pneumoniae, or P. mirabilis. From each patient only the first isolate from the infection site was included. Antimicrobial susceptibility was determined by the disc diffusion method.Results: Overall 827 patients were included, and 354 (42.8%) came from the community and 473 (57.2%) were referred from nursing home. Of the isolates acquired in nursing home, 45.5% (215/473) harbored ESBL. In contrast, 20.6% (73/354) isolates acquired in the community exhibited the ESBL production phenotype (P<0.001). Of the isolates obtained from blood, urine, or sputum, 28.2% (37/131), 36.0% (208/578), or 36.4% (43/118) harbored ESBL, respectively, whereas 41% (211) of 515 E. coli isolates, 34.3% (72) of 210 K. pneumoniae, and 4.9% (5) of 102 P. mirabilis had ESBL. In general, the isolates from nursing home or those with ESBL had lower antimicrobial susceptibility rates than those from the community or those without ESBL production. Only amikacin, piperacillin/tazobactam, ertapenem, and imipenem/meropenem were active against >90% Enterobacteriaceae isolates, irrespective of ESBL production.Conclusion: ESBL production was common among clinical Enterobacteriaceae isolates, esp. E. oli or those isolated from nursing home residents.
    日期: 2015-04
    關聯: Journal of Microbiology, Immunology and Infection. 2015 Apr;48(2, Suppl. 1):S139-S140.
    Link to: http://dx.doi.org/10.1016/j.jmii.2015.02.490
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1684-1182&DestApp=IC2JCR
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