English  |  正體中文  |  简体中文  |  Items with full text/Total items : 12145/12927 (94%)
Visitors : 854159      Online Users : 1521
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
    •  Adv. Search
    Home ‧ Login ‧ Upload ‧ Help ‧ About ‧ Administer Goto mobile version


    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/8630


    Title: Emergence of OXA-48 Carbapenemase in Taiwan
    Authors: Ma, L;Chen, P;Lin, F;Ding, Y;Huang, L;Chang, J;Liu, Q;Tai, Y;Lu, P
    Contributors: Division of Infectious Diseases
    Abstract: Purpose: OXA-48 producing Enterbacteriaceae are increased dramatically in Mediterranean countries in the past ten years. It has been found in Asia recently. Here, we report the emergence of OXA-48 during a nationwide survey in Taiwan. Methods: A 4 year carbapenem resistant Enterobacteriaceae surveillance program was conducted from 2012. From 2012 to May 2014, we obatained 760 carbapenem non-susceptible K. pneumoniae (CnSKP) and 144 carbapenem non-susceptible E.coli (CnSEC) isolates till April 2014. Antibiotics susceptibility test, detection of carbapenemase, ESBLs and AmpC, outer membrane porin (omp) profiles and genetic relationship with PFGE and MLST were performed. Results: Four OXA-48 producing K.pneumoniae were detected after 28 month screening. The OXA-48 gene is encoded by a conjugative plasmid and associated with IS1999. The upstream of blaOXA-48 identical to pKoxa-48N1, four plasmids showed similar digestion profiles, the plasmid size was predicted over 62Kb. Three isolates co-produced CTX-M enzyme and belong to ST11, their plasmid belong to Inc A/C. Four isolates belong to three different clones. Conclusions: It is the second report of OXA-48 on IncA/C plasmid in K.pneumoniae. The association OXA-48 and CTX-M lead to pan-resistance. Taking into account the pandemic clone of ST11 K.pneumoniae and incorporation of Inc A/C plasmid, the rapid dissemination of ST11 OXA-48 combined with CTX-M ESBL is of great concern.
    Date: 2015-04
    Relation: Journal of Microbiology, Immunology and Infection. 2015 Apr;48(2, Suppl.1):S107.
    Link to: http://dx.doi.org/10.1016/j.jmii.2015.02.378
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1684-1182&DestApp=IC2JCR
    Appears in Collections:[其他] 會議論文/會議摘要

    Files in This Item:

    File Description SizeFormat
    SDO1684118215004119.pdf403KbAdobe PDF529View/Open


    All items in NHRI are protected by copyright, with all rights reserved.

    Related Items in TAIR

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback