國家衛生研究院 NHRI:Item 3990099045/8630
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    題名: Emergence of OXA-48 Carbapenemase in Taiwan
    作者: Ma, L;Chen, P;Lin, F;Ding, Y;Huang, L;Chang, J;Liu, Q;Tai, Y;Lu, P
    貢獻者: Division of Infectious Diseases
    摘要: Purpose: OXA-48 producing Enterbacteriaceae are increased dramatically in Mediterranean countries in the past ten years. It has been found in Asia recently. Here, we report the emergence of OXA-48 during a nationwide survey in Taiwan. Methods: A 4 year carbapenem resistant Enterobacteriaceae surveillance program was conducted from 2012. From 2012 to May 2014, we obatained 760 carbapenem non-susceptible K. pneumoniae (CnSKP) and 144 carbapenem non-susceptible E.coli (CnSEC) isolates till April 2014. Antibiotics susceptibility test, detection of carbapenemase, ESBLs and AmpC, outer membrane porin (omp) profiles and genetic relationship with PFGE and MLST were performed. Results: Four OXA-48 producing K.pneumoniae were detected after 28 month screening. The OXA-48 gene is encoded by a conjugative plasmid and associated with IS1999. The upstream of blaOXA-48 identical to pKoxa-48N1, four plasmids showed similar digestion profiles, the plasmid size was predicted over 62Kb. Three isolates co-produced CTX-M enzyme and belong to ST11, their plasmid belong to Inc A/C. Four isolates belong to three different clones. Conclusions: It is the second report of OXA-48 on IncA/C plasmid in K.pneumoniae. The association OXA-48 and CTX-M lead to pan-resistance. Taking into account the pandemic clone of ST11 K.pneumoniae and incorporation of Inc A/C plasmid, the rapid dissemination of ST11 OXA-48 combined with CTX-M ESBL is of great concern.
    日期: 2015-04
    關聯: Journal of Microbiology, Immunology and Infection. 2015 Apr;48(2, Suppl.1):S107.
    Link to: http://dx.doi.org/10.1016/j.jmii.2015.02.378
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1684-1182&DestApp=IC2JCR
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