國家衛生研究院 NHRI:Item 3990099045/8643
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 12145/12927 (94%)
造访人次 : 916313      在线人数 : 1446
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于NHRI ‧ 管理 到手机版
    國家衛生研究院 NHRI > 癌症研究所 > 其他 > 期刊論文 >  Item 3990099045/8643


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/8643


    题名: Skp2-MacroH2A1-CDK8 axis orchestrates G2/M transition and tumorigenesis
    作者: Xu, D;Li, CF;Zhang, X;Gong, Z;Chan, CH;Lee, SW;Jin, G;Rezaeian, AH;Han, F;Wang, J;Yang, WL;Feng, ZZ;Chen, W;Wu, CY;Wang, YJ;Chow, LP;Zhu, XF;Zeng, YX;Lin, HK
    贡献者: National Institute of Cancer Research
    摘要: Understanding the mechanism by which cell growth, migration, polyploidy, and tumorigenesis are regulated may provide important therapeutic strategies for cancer therapy. Here we identify the Skp2-macroH2A1 (mH2A1)-cyclin-dependent kinase 8 (CDK8) axis as a critical pathway for these processes, and deregulation of this pathway is associated with human breast cancer progression and patient survival outcome. We showed that mH2A1 is a new substrate of Skp2 SCF complex whose degradation by Skp2 promotes CDK8 gene and protein expression. Strikingly, breast tumour suppression on Skp2 deficiency can be rescued by mH2A1 knockdown or CDK8 restoration using mouse tumour models. We further show that CDK8 regulates p27 protein expression by facilitating Skp2-mediated p27 ubiquitination and degradation. Our study establishes a critical role of Skp2-mH2A1-CDK8 axis in breast cancer development and targeting this pathway offers a promising strategy for breast cancer therapy.
    日期: 2015-03-30
    關聯: Nature Communications. 2015 Mar 30;6:Article number 6641.
    Link to: http://dx.doi.org/10.1038/ncomms7641
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2041-1723&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000353040400001
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?eid=2-s2.0-84926320663partnerID=40
    显示于类别:[其他] 期刊論文

    文件中的档案:

    档案 大小格式浏览次数
    PUB25818643.pdf2512KbAdobe PDF314检视/开启


    在NHRI中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈