國家衛生研究院 NHRI:Item 3990099045/8690
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    題名: LED 590nm photomodulation reduces UVA-induced metalloproteinase-1 expression via upregulation of antioxidant enzyme catalase
    作者: Lan, CCE;Ho, PY;Wu, CS;Yang, RC;Yu, HS
    貢獻者: National Institute of Environmental Health Sciences
    摘要: Background: Light at visible spectrum has been associated with anti-inflammatory and anti-aging effects. Ultraviolet A (UVA) radiation is the most important environmental factor associated with exogenous aging via induction of reactive oxygen species (ROS). Objective: In this study, we focused on elucidating the molecular mechanisms involved in biological effects associated with 590. nm light delivered from light emitting diode (LED). Methods: UVA-induced metalloproteinase-1 (MMP-1) expression in dermal fibroblast was used as a model system for investigation. Results: Pretreating cultured human fibroblasts with 590. nm light attenuated UVA-induced ROS, phosphorylated Jun N-terminal kinases, and MMP-1 expressions in a sequential manner. Pretreatment with potent antioxidant N-acetylcysteine produced similar effect, suggesting enhanced antioxidant capacity induced by 590. nm photomodulation. Further experiments demonstrated that 590. nm photomodulation attenuated UVA-induced ROS and MMP-1 expressions via mitochondrial retrograde signaling that augments the antioxidant enzyme expression in a peroxisome proliferators-activated receptor γ coactivator-1α-dependent manner. Conclusion: Our results provided possible mechanistic insights explaining the effect of visible light on treating clinical conditions associated with ROS-mediated dysfunctions.
    日期: 2015-05
    關聯: Journal of Dermatological Science. 2015 May;78(2):125-132.
    Link to: http://dx.doi.org/10.1016/j.jdermsci.2015.02.018
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0923-1811&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000354502800006
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84927043120
    顯示於類別:[余幸司] 期刊論文

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