國家衛生研究院 NHRI:Item 3990099045/8693

NHRI > National Institute of Environmental Health Sciences > Saou-Hsing Liou > Periodical Articles > Item 3990099045/8693

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/8693

Title:	The impact of obstructive sleep apnea on high-sensitivity C-reactive protein in subjects with or without metabolic syndrome
Authors:	Wu, WT;Tsai, SS;Shih, TS;Lin, MH;Chou, TC;Ting, H;Wu, TN;Liou, SH
Contributors:	National Institute of Environmental Health Sciences
Abstract:	Background: It is unclear whether obstructive sleep apnea (OSA) is independently associated with increased levels of the acute-phase reactant C-reactive protein (CRP). The purpose of this study was to evaluate the relationship between OSA and high-sensitivity CRP (hs-CRP) levels according to the presence or absence of metabolic syndrome (MetS). Methods: This study recruited 245 male bus drivers from one transportation company in Taiwan. Each participant was evaluated by a polysomnography (PSG) test, blood lipids examination, and hs-CRP. Severity of OSA was categorized according to the apnea-hypopnea index (AHI). Results: Subjects were categorized into severe OSA group (n = 44; 17.9 %), moderate and mild OSA group (n = 117; 47.8 %), and non-OSA group (n = 84; 34.3 %). AHI had a significant association with hs-CRP (β = 0.125, p = 0.009) adjusting for age, smoking, drinking, and MetS status. Hs-CRP was elevated with severe OSA (β = 0.533, p = 0.005) even adjusting for BMI and MetS. Moreover, there was an independent effect for adjusted odds ratios (AORs) between the stratification of the severity for OSA and MetS. Conclusion: Elevated hs-CRP level is associated with severe OSA, independent of known confounders. The effect of OSA in CRP is independent of MetS was identified.
Date:	2015-12
Relation:	Sleep and Breathing. 2015 Dec;19(4):1449-1457.
Link to:	http://dx.doi.org/10.1007/s11325-015-1166-2
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1520-9512&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000365744500049
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84949100492
Appears in Collections:	[Saou-Hsing Liou] Periodical Articles [Wei-Te Wu] Periodical Articles

Files in This Item:

File	Description	Size	Format
SCP84926611675.pdf		412Kb	Adobe PDF	529	View/Open

Loading...