鄰近類別 會議論文/會議摘要 [6/8] 報告 [0/1] 專利 [0/10] 類別統計 近3年內發表的文件:1(2.17%) 含全文筆數:46(100.00%) 文件下載次數統計 下載大於0次:46(100.00%) 下載大於100次:46(100.00%) 檔案下載總次數:35563(90.59%) 最後更新時間: 2024-11-28 23:45 上傳排行 資料載入中..... 下載排行 資料載入中..... 最近上傳 Discovery and development of a nove... Xanthine derivatives reveal an allo... Unique sulfur-aromatic interactions... Identification of a multitargeted t... Discovery of a furanopyrimidine-bas... Discovery of Conformational Control... 4-Bromophenylhydrazinyl benzenesulf... Mutagenesis of dengue virus protein... Pyrazolylamine derivatives reveal t... Phenyl benzenesulfonylhydrazides ex...

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日期	題名	關聯
2022-02-05	Discovery and development of a novel N-(3-bromophenyl)-{[(phenylcarbamoyl)amino]methyl}-N-hydroxythiophene-2-carboximidamide indoleamine 2,3-dioxygenase inhibitor using knowledge-based drug design	European Journal of Medicinal Chemistry. 2022 Feb 5;229:Article number 114043.
2021-08-12	Xanthine derivatives reveal an allosteric binding site in methylenetetrahydrofolate dehydrogenase 2 (MTHFD2)	Journal of Medicinal Chemistry. 2021 Aug 12;64(15):11288-11301.
2020-02-10	Unique sulfur-aromatic interactions contribute to the binding of potent imidazothiazole indoleamine 2,3-Dioxygenase inhibitors	Journal of Medicinal Chemistry. 2020 Feb 10;63(4):1642-1659.
2019-12	Identification of a multitargeted tyrosine kinase inhibitor for the treatment of gastrointestinal stromal tumors and acute myeloid leukemia	Journal of Medicinal Chemistry. 2019 Dec;62(24):11135-11150.
2019-11-27	Discovery of a furanopyrimidine-based epidermal growth factor receptor inhibitor (DBPR112) as a clinical candidate for the treatment of non-small cell lung cancer	Journal of Medicinal Chemistry. 2019 Nov 27;62(22):10108-10123.
2019-04-10	Discovery of Conformational Control Inhibitors Switching off the Activated c-KIT and Targeting a Broad Range of Clinically Relevant c-KIT Mutants	Journal of Medicinal Chemistry. 2019 Apr 10;62(8):3940-3957.
2018-04	4-Bromophenylhydrazinyl benzenesulfonylphenylureas as indoleamine 2,3-dioxygenase inhibitors with in vivo target inhibition and anti-tumor efficacy	Bioorganic Chemistry. 2018 Apr;77:600-607.
2017-06	Mutagenesis of dengue virus protein NS2A revealed a novel domain responsible for virus-induced cytopathic effect and interactions between NS2A and NS2B transmembrane segments	Journal of Virology. 2017 Jun;91(12):Article number e01836-16.
2016-04-12	Pyrazolylamine derivatives reveal the conformational switching between type I and type II binding modes of Anaplastic Lymphoma Kinase (ALK)	Journal of Medicinal Chemistry. 2016 Apr 12;59(8):3906-3919.
2016-01	Important hydrogen bond networks in Indoleamine 2,3-Dioxygenase 1 (IDO1) inhibitor design revealed by crystal structures of imidazoleisoindole derivatives with IDO1	Journal of Medicinal Chemistry. 2016 Jan;59 (1):282-293.

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