邻近类别 會議論文/會議摘要 [6/8] 報告 [0/1] 專利 [0/10] 类别统计 近3年内发表的文件:1(2.17%) 含全文笔数:46(100.00%) 文件下载次数统计 下载大于0次:46(100.00%) 下载大于100次:46(100.00%) 全文下载总次数:35616(90.60%) 最后更新时间: 2024-12-01 11:30 上传排行 数据加载中..... 下载排行 数据加载中..... 最近上传 Discovery and development of a nove... Xanthine derivatives reveal an allo... Unique sulfur-aromatic interactions... Identification of a multitargeted t... Discovery of a furanopyrimidine-bas... Discovery of Conformational Control... 4-Bromophenylhydrazinyl benzenesulf... Mutagenesis of dengue virus protein... Pyrazolylamine derivatives reveal t... Phenyl benzenesulfonylhydrazides ex...

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日期	题名	關聯
2022-02-05	Discovery and development of a novel N-(3-bromophenyl)-{[(phenylcarbamoyl)amino]methyl}-N-hydroxythiophene-2-carboximidamide indoleamine 2,3-dioxygenase inhibitor using knowledge-based drug design	European Journal of Medicinal Chemistry. 2022 Feb 5;229:Article number 114043.
2021-08-12	Xanthine derivatives reveal an allosteric binding site in methylenetetrahydrofolate dehydrogenase 2 (MTHFD2)	Journal of Medicinal Chemistry. 2021 Aug 12;64(15):11288-11301.
2020-02-10	Unique sulfur-aromatic interactions contribute to the binding of potent imidazothiazole indoleamine 2,3-Dioxygenase inhibitors	Journal of Medicinal Chemistry. 2020 Feb 10;63(4):1642-1659.
2019-12	Identification of a multitargeted tyrosine kinase inhibitor for the treatment of gastrointestinal stromal tumors and acute myeloid leukemia	Journal of Medicinal Chemistry. 2019 Dec;62(24):11135-11150.
2019-11-27	Discovery of a furanopyrimidine-based epidermal growth factor receptor inhibitor (DBPR112) as a clinical candidate for the treatment of non-small cell lung cancer	Journal of Medicinal Chemistry. 2019 Nov 27;62(22):10108-10123.
2019-04-10	Discovery of Conformational Control Inhibitors Switching off the Activated c-KIT and Targeting a Broad Range of Clinically Relevant c-KIT Mutants	Journal of Medicinal Chemistry. 2019 Apr 10;62(8):3940-3957.
2018-04	4-Bromophenylhydrazinyl benzenesulfonylphenylureas as indoleamine 2,3-dioxygenase inhibitors with in vivo target inhibition and anti-tumor efficacy	Bioorganic Chemistry. 2018 Apr;77:600-607.
2017-06	Mutagenesis of dengue virus protein NS2A revealed a novel domain responsible for virus-induced cytopathic effect and interactions between NS2A and NS2B transmembrane segments	Journal of Virology. 2017 Jun;91(12):Article number e01836-16.
2016-04-12	Pyrazolylamine derivatives reveal the conformational switching between type I and type II binding modes of Anaplastic Lymphoma Kinase (ALK)	Journal of Medicinal Chemistry. 2016 Apr 12;59(8):3906-3919.
2016-01	Important hydrogen bond networks in Indoleamine 2,3-Dioxygenase 1 (IDO1) inhibitor design revealed by crystal structures of imidazoleisoindole derivatives with IDO1	Journal of Medicinal Chemistry. 2016 Jan;59 (1):282-293.
2016-01	Phenyl benzenesulfonylhydrazides exhibit selective Indoleamine 2,3-Dioxygenase inhibition with potent in vivo pharmacodynamic activity and antitumor efficacy	Journal of Medicinal Chemistry. 2016 Jan;59(1):419-430.
2015-10	Identification of substituted naphthotriazolediones as novel tryptophan 2,3-dioxygenase (TDO) inhibitors through structure-based virtual screening	Journal of Medicinal Chemistry. 2015 Oct;58 (19):7807-7819.
2014-08	Discovery and structure-activity relationships of phenyl benzenesulfonylhydrazides as novel indoleamine 2,3-dioxygenase inhibitors	Bioorganic and Medicinal Chemistry Letters. 2014 Aug;24(15):3403-3406.
2013-09	Furanylazaindoles: Potent anticancer agents in vitro and in vivo	Journal of Medicinal Chemistry. 2013 Sep;56(20):8008-8018.
2013-05	Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules	Proceedings of the National Academy of Sciences of the United States of America. 2013 May;110(19):E1779-E1787.
2013-05	Protein kinase inhibitor design by targeting the Asp-Phe-Gly (DFG) motif: The role of the DFG motif in the design of epidermal growth factor receptor inhibitors	Journal of Medicinal Chemistry. 2013 May;56(10):3889-3903.
2013-02	Resistance studies of a di-thiazol analogue, DBPR110, as a potential hepatitis C virus NS5A inhibitor in replicon systems	Antimicrobial Agents and Chemotherapy. 2013 Feb; 57(2):723-733.
2012-08	Development of an anti-influenza drug screening assay targeting nucleoproteins with tryptophan fluorescence quenching	Analytical Chemistry. 2012 Aug;84(15):6391-6399.
2012-02	Discovery of novel stem cell mobilizers that target the CXCR4 receptor	ChemMedChem. 2012 Feb;7(2):209-212.
2011-09	Synthesis and biological evaluation of 1-(4′-Indolyl and 6′-Quinolinyl) indoles as a new class of potent anticancer agents	European Journal of Medicinal Chemistry. 2011 Sep;46(9):3623-3629.
2011-04-28	Scaffold-hopping strategy: Synthesis and biological evaluation of 5,6-Fused bicyclic heteroaromatics to identify orally bioavailable anticancer agents	Journal of Medicinal Chemistry. 2011 Apr 28;54(8):3076-3080.
2010-12	Discovery of non-glycoside sodium-dependent glucose Co-transporter 2 (SGLT2) inhibitors by ligand-based virtual screening	Journal of Medicinal Chemistry. 2010 Dec;53(24):8770-8774.
2010-10	Structural basis for the improved potency of peroxisome proliferator-activated receptor (PPAR) agonists	ChemMedChem. 2010 Oct;5(10):1707-1716.
2010-09	Cancer cells acquire mitotic drug resistance properties through beta i-tubulin mutations and alterations in the expression of beta-tubulin isotypes	PLoS ONE. 2010 Sep;5(9):Article number e12564.
2010-06-15	Fast-forwarding hit to lead: Aurora and epidermal growth factor receptor kinase inhibitor lead identification	Journal of Medicinal Chemistry. 2010 Jun 15;53(13):4980-4988.
2010-03-11	5-Amino-2-Aroylquinolines as Highly Potent Tubulin Polymerization Inhibitors	Journal of Medicinal Chemistry. 2010 Mar 11;53(5):2309-2313.
2010-02-01	Identification, SAR studies, and X-ray Co-crystallographic analysis of a novel furanopyrimidine aurora kinase a inhibitor	ChemMedChem. 2010 Feb 1;5(2):255-267.
2009-10	(1,3-Diphenyl-1H-pyrazol-4-yl)-methylamine analogues as inhibitors of dipeptidyl peptidases	Journal of the Chinese Chemical Society. 2009 Oct;56(5):1048-1055.
2009-08-13	Synthesis and evaluation of 3-aroylindoles as anticancer agents: Metabolite approach	Journal of Medicinal Chemistry. 2009 Aug 13;52(15):4941-4945.
2009-07-23	Generation of ligand-based pharmacophore model and virtual screening for identification of novel tubulin inhibitors with potent anticancer activity	Journal of Medicinal Chemistry. 2009 Jul 23;52(14):4221-4233.
2009-06	A three-dimensional pharmacophore model for dipeptidyl peptidase IV inhibitiors [Erratum: European Journal of Medicinal Chemistry. 2008 Aug;43(8):1603-1611.]	European Journal of Medicinal Chemistry. 2009 Jun;44(6):2763-2763.
2009-04-23	Design and structural analysis of novel pharmacophores for potent and selective peroxisome proliferator-activated receptor gamma agonists	Journal of Medicinal Chemistry. 2009 Apr 23;52(8):2618-2622.
2009-02-26	Structure-based drug design of novel aurora kinase a inhibitors: Structural basis for potency and specificity	Journal of Medicinal Chemistry. 2009 Feb 26;52(4):1050-1062.
2008-12-25	Synthesis and structure-activity relationships of 2-amino-1-aroylnaphthalene and 2-hydroxy-1-aroylnaphthalenes as potent antitubulin agents	Journal of Medicinal Chemistry. 2008 Dec 25;51(24):8163-8167.
2008-08	A three-dimensional pharmacophore model for dipeptidyl peptidase IV inhibitors	European Journal of Medicinal Chemistry. 2008 Aug;43(8):1603-1611.
2008-03-01	Aurora kinase A inhibitors: Identification, SAR exploration and molecular modeling of 6,7-dihydro-4H-pyrazolo-[1,5-a]pyrrolo[3,4-d]pyrimidine-5,8-dione scaffold	Bioorganic and Medicinal Chemistry Letters. 2008 Mar;18(5):1623-1627.
2008	Structure-based inhibitors exhibit differential activities against Helicobacter pylori and Escherichia coli undecaprenyl pyrophosphate synthases	Journal of Biomedicine and Biotechnology. 2008; 2008:Article number 841312.
2006-10-19	Structural basis for the structure-activity relationships of peroxisome proliferator-activated receptor agonists	Journal of Medicinal Chemistry. 2006 Oct;49(21):6421-6424.
2006-08-24	Structure-based drug design and structural biology study of novel nonpeptide inhibitors of severe acute respiratory syndrome coronavirus main protease	Journal of Medicinal Chemistry. 2006 Aug;49(17):5154-5161.
2006-06-15	Discovery of a novel family of SARS-CoV protease inhibitors by virtual screening and 3D-QSAR studies	Journal of Medicinal Chemistry. 2006 Jun;49(12):3485-3495.
2006-05-04	Structure-based drug design of a novel family of PPAR gamma partial agonists: Virtual screening, X-ray crystallography, and in vitro/in vivo biological activities	Journal of Medicinal Chemistry. 2006 May;49(9):2703-2712.
2006-02-09	Indol-1-yl acetic acids as peroxisome proliferator-activated receptor agonists: Design, synthesis, structural biology, and molecular docking studies	Journal of Medicinal Chemistry. 2006 Feb;49(3):1212-1216.
2006-01-12	2-[3-[2-[(2S)-2-cyano-1-pyrrolidinyl]-2-oxoethylamino]-3-methyl-1-oxobutyl]-1,2,3,4-tetrahydroisoquinoline: A potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV	Journal of Medicinal Chemistry. 2006 Jan;49(1):373-380.
2005-12-29	Novel indole-based peroxisome proliferator-activated receptor agonists: Design, SAR, structural biology, and biological activities	Journal of Medicinal Chemistry. 2005 Dec;48(26):8194-8208.
2005-12-15	The effect of N-terminal truncation on double-dimer assembly of goose delta-crystallin	Biochemical Journal. 2005 Dec;392(Pt. 3):545-554.
2005-07-01	Glutamic acid analogues as potent dipeptidyl peptidase IV and 8 inhibitors	Bioorganic and Medicinal Chemistry Letters. 2005 Jul;15(13):3271-3275.

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