國家衛生研究院 NHRI:Item 3990099045/8794

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Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/8794

Title:	Association of prior antiplatelet agents with mortality in sepsis patients: A nationwide population-based cohort study
Authors:	Tsai, MJ;Ou, SM;Shih, CJ;Chao, PW;Wang, LF;Shih, YN;Li, SY;Kuo, SC;Hsu, YT;Chen, YT
Contributors:	Division of Infectious Diseases
Abstract:	Antiplatelet agents are widely used for cardiovascular disea ses, but their pleiotropic effects in sepsis are controversial. To investigate the association between antiplatelet agents and the survival benefit for sepsis patients. A nationwide population-based cohort and nested case-control study. Taiwan National Health Insurance database. All patients (age a parts per thousand yen18 years) who were hospitalized for sepsis between January 2000 and December 2010. Conditional logistic regression was used to adjust for confounding. Adjusted odd ratios (ORs) were used to compare the mortality rate due to sepsis in antiplatelet drug users and nonusers. Of 683,421 included patients, 229,792 (33.6 %) patients died during hospitalization for sepsis, and the rest (64.4 %) survived to discharge. Use of antiplatelet agents before admission was associated with a lower risk of mortality in sepsis patients (aOR 0.82, 95 % confidence interval [CI] 0.81-0.83, P < 0.001). By using another case-control study design, the beneficial effect was more significant in current users (aOR 0.78, 95 % CI 0.76-0.79) than in recent users (aOR 0.88, 95 % CI 0.85-0.91), but was not significant in past users (aOR 1.00, 95 % CI 0.98-1.02). Observational study. Prior use of antiplatelet agents was associated with a survival benefit in sepsis patients.
Date:	2015-05
Relation:	Intensive Care Medicine. 2015 May;41(5):806-813.
Link to:	http://dx.doi.org/10.1007/s00134-015-3760-y
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0342-4642&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000353841600006
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84937761924
Appears in Collections:	[Shu-Chen Kuo] Periodical Articles

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