國家衛生研究院 NHRI:Item 3990099045/8797
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    题名: Prefrontal glucose metabolism in medication-resistant major depression
    作者: Li, CT;Su, TP;Wang, SJ;Tu, PC;Hsieh, JC
    贡献者: Center for Neuropsychiatric Research
    摘要: Background Medication-resistant depression (MRD) is associated with poorer attentional performance and immense socioeconomic costs. Aims We aimed to investigate the central pathophysiology of MRD, previously linked to impaired prefrontal cortex function. Method A total of 54 participants (22 with MRD, 16 with non-resistant depression, 16 healthy controls) were recruited. Non-MRD status was confirmed by a prospective 6-week antidepressant trial. All medication-free participants underwent a go/no-go task to study prefrontal cortical function (attention) and positron emission tomography scans to study regional cerebral glucose metabolism (rCMglu) at rest. Results The MRD group had worse attentional ratings and decreased rCMglu compared with the non-MRD and control groups. Attentional performance was positively associated with prefrontal cortex rCMglu. The prefrontal cortex differences between MRD and non-MRD groups remained after adjusting for past depressive episodes (F-(1,F-35) = 4.154, P = 0.043). Conclusions Pronounced hypofrontality, with the associated attentional deficits, has a key role in the neuropathology of medication-resistant depression.
    日期: 2015-04
    關聯: British Journal of Psychiatry. 2015 Apr;206(4):316-323.
    Link to: http://dx.doi.org/10.1192/bjp.bp.113.140434
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0007-1250&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000352680400011
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