國家衛生研究院 NHRI:Item 3990099045/8800
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/8800


    Title: Chemokine IP-10 is correlated with cardiac responses and status of infection with HIV and HCV in methadone maintenance patients
    Authors: Liu, SW;Liu, YL;Hwang, LL;Wang, SC;Kuo, HW;Wu, SL;Dai, YWE;Liu, SC;Ho, IK;Chen, ACH;Hsiao, CF;Tsou, HH
    Contributors: Center for Neuropsychiatric Research;Division of Biostatistics and Bioinformatics;Division of Clinical Trial Statistics
    Abstract: To the Editor,Methadone is a synthetic opioid usually used as a maintenance therapy for heroin dependence [1]. It has been reported that the infection rates with human immunodeficiency virus (HIV) and/or hepatitis C virus (HCV) were higher in patients undergoing methadone maintenance treatment (MMT) [2]. However, the influence of co-infection with HIV and HCV on the treatment responses to methadone has yet to be studied. A higher plasma level of chemokine interferon gamma-inducible protein 10 (IP-10, also called chemokine (C-X-C motif) ligand 10, CXCL 10) has been reported in patients infected with both HIV and HCV than those infected with only single virus [3]. Increased expression of IP-10, CXCR3 receptors in the CD8(+) lymphocytes has also been reported in patients co-infected with HIV and HCV [4]. Furthermore, IP-10 has been suggested as a biomarker for predicting the HCV treatment outcome for patients infected with both HIV and HCV [5]. However, the influence of chemokines/cytokines on the treatment responses to methadone and HIV/HCV infection remains unclear.We recruited 366 Han Chinese subjects with heroin dependence undergoing MMT in outpatient settings in Taiwan to investigate the impact of HIV/HCV infection on the levels of chemokines or cytokines and the treatment responses to methadone. 331 patients were screened for HCV, and 329 for HIV antibody. Detailed demography of subjects is shown in Table 1. Only one patient was tested positive for HIV-antibody but not HCV, hence it was excluded from further analysis because of the small sample size. A higher initial methadone dose (P = 0.038), higher plasma concentrations of (R,S)-methadone (P = 0.038) and R-methadone (P = 0.028), lower ratio of S-EDDP/methadone dose (P = 0.043), higher levels of AST (P = 0.048) and ALT (P = 0.046), and a longer addiction duration (P < 0.0001) were found in the HIV(+)/HCV(+) or HCV(+) patients than the HIV(−)/HCV(−) patients ( Table 1). The results of urine morphine test, which was used as a surrogate indicator for the effectiveness of opioid dependence treatment [6], were not statistically different among subjects grouped by their status of HIV and/or HCV infection.
    Date: 2015-09-01
    Relation: International Journal of Cardiology. 2015 Sep 1;194:36-38.
    Link to: http://dx.doi.org/10.1016/j.ijcard.2015.05.055
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0167-5273&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000356053900008
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84930946029
    Appears in Collections:[Sheng-Chang Wang] Periodical Articles
    [Yu-Li Liu] Periodical Articles
    [Hsiao-Hui Sophie Tsou] Periodical Articles
    [Chin-Fu Hsiao] Periodical Articles

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