國家衛生研究院 NHRI:Item 3990099045/8801
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    题名: Vitamin E intake from natural sources and head and neck cancer risk: A pooled analysis in the International Head and Neck Cancer Epidemiology Consortium
    作者: Edefonti, V;Hashibe, M;Parpinel, M;Ferraroni, M;Turati, F;Serraino, D;Matsuo, K;Olshan, AF;Zevallos, JP;Winn, DM;Moysich, K;Zhang, ZF;Morgenstern, H;Levi, F;Kelsey, K;McClean, M;Bosetti, C;Schantz, S;Yu, GP;Boffetta, P;Chuang, SC;YC, AL;La Vecchia, C;Decarli, A
    贡献者: Division of Health Policy Translation
    摘要: BACKGROUND: Evidence for the possible effect of vitamin E on head and neck cancers (HNCs) is limited. METHODS: We used individual-level pooled data from 10 case-control studies (5959 cases and 12 248 controls) participating in the International Head and Neck Cancer Epidemiology (INHANCE) consortium to assess the association between vitamin E intake from natural sources and cancer of the oral cavity/pharynx and larynx. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression models applied to quintile categories of nonalcohol energy-adjusted vitamin E intake. RESULTS: Intake of vitamin E was inversely related to oral/pharyngeal cancer (OR for the fifth vs the first quintile category=0.59, 95% CI: 0.49-0.71; P for trend <0.001) and to laryngeal cancer (OR=0.67, 95% CI: 0.54-0.83, P for trend <0.001). There was, however, appreciable heterogeneity of the estimated effect across studies for oral/pharyngeal cancer. Inverse associations were generally observed for the anatomical subsites of oral and pharyngeal cancer and within covariate strata for both sites. CONCLUSION: Our findings suggest that greater vitamin E intake from foods may lower HNC risk, although we were not able to explain the heterogeneity observed across studies or rule out certain sources of bias.
    日期: 2015-06
    關聯: British Journal of Cancer. 2015 Jun;113(1):182-192.
    Link to: http://dx.doi.org/10.1038/bjc.2015.149
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0007-0920&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000357188500026
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84934439124
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