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Please use this identifier to cite or link to this item:
http://ir.nhri.org.tw/handle/3990099045/8831
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| Title: | miR-520h is crucial for DAPK2 regulation and breast cancer progression |
| Authors: | Su, CM;Wang, MY;Hong, CC;Chen, HA;Su, YH;Wu, CH;Huang, MT;Chang, YW;Jiang, SS;Sung, SY;Chang, JY;Chen, LT;Chen, PS;Su, JL |
| Contributors: | National Institute of Cancer Research |
| Abstract: | MicroRNAs (miRNAs) are small RNAs that suppress gene expression by their interaction with 3'untranslated region of specific target mRNAs. Although the dysregulation of miRNAs has been identified in human cancer, only a few of these miRNAs have been functionally documented in breast cancer. Thus, defining the important miRNA and functional target involved in chemoresistance is an urgent need for human breast cancer treatment. In this study, we, for the first time, identified a key role of miRNA 520h (miR-520h) in drug resistance. Through protecting cells from paclitaxel-induced apoptosis, expression of miR-520h promoted the drug resistance of human breast cancer cells. Bioinformatics prediction, compensatory mutation and functional validation further confirmed the essential role of miR-520h-suppressed Death-associated protein kinase 2 (DAPK2) expression, as restoring DAPK2 abolished miR-520h-promoted drug resistance, and knockdown of DAPK2 mitigated cell death caused by the depletion of miR-520h. Furthermore, we observed that higher level of miR-520h is associated with poor prognosis and lymph node metastasis in human breast cancer patients. These results show that miR-520h is not only an independent prognostic factor, but is also a potential functional target for future applications in cancer therapeutics. |
| Date: | 2016-03 |
| Relation: | Oncogene. 2016 Mar 3;35(9):1134-1142. |
| Link to: | http://dx.doi.org/10.1038/onc.2015.168 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0950-9232&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:000371351700007 |
| Cited Times(Scopus): | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84959485225 |
| Appears in Collections: | [蘇振良] 期刊論文
[陳立宗] 期刊論文
[張俊彥] 期刊論文
[江士昇] 期刊論文
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