國家衛生研究院 NHRI:Item 3990099045/8833
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/8833


    Title: Quality of life changes in patients undergoing treatment for hepatocellular carcinoma
    Authors: Chie, WC;Yu, F;Li, M;Baccaglini, L;Blazeby, JM;Hsiao, CF;Chiu, HC;Poon, RT;Mikoshiba, N;Al-Kadhimi, G;Heaton, N;Calara, J;Collins, P;Caddick, K;Costantini, A;Vilgrain, V;Chiang, C
    Contributors: Division of Clinical Trial Statistics
    Abstract: Purpose: Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death worldwide. One of the primary treatment goals for incurable advanced cases is to prolong quality of life (QoL). Thus, to determine which HCC therapies may be linked to a more favorable QoL, we assessed the association between QoL changes and different treatments in HCC patients. Methods: We analyzed a non-randomized multicenter longitudinal study, which included 171 patients treated with surgery (n = 53), ablation (n = 53) or embolization (n = 65) from seven centers: four Asian and three European sites. All participants completed the EORTC QLQ-C30 and QLQ-HCC18 questionnaires before and after treatment. Propensity scores were calculated and used in addition to race for adjustment in the logistic regression model to account for the confounding effects of patient characteristics including age, gender, race, employment, living with family, at least one comorbid condition, years since diagnosis, prior treatment history, BCLC stage, Child–Pugh grade, cirrhosis, bilirubin levels and QoL score before treatment. Results: After adjustment for confounders, patients tended to have higher odds of QoL deterioration when treated with ablation versus embolization (dyspnea: p = 0.019; appetite loss: p = 0.018; body image: p = 0.035) or ablation versus surgery (dyspnea: p = 0.099; appetite loss: p = 0.100; body image: p = 0.038). Conclusions: There were significant differences in QoL deterioration across different treatment groups. This information may assist patients and providers when selecting patient-centered treatment approaches for HCC.
    Date: 2015-10
    Relation: Quality of Life Research. 2015 Oct;24(10):2499-2506.
    Link to: http://dx.doi.org/10.1007/s11136-015-0985-8
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0962-9343&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000361010400020
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84941413113
    Appears in Collections:[Chin-Fu Hsiao] Periodical Articles

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