國家衛生研究院 NHRI:Item 3990099045/8842
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    题名: Prussian blue derived nanoporous iron oxides as anticancer drug carriers for magnetic-guided chemotherapy
    作者: Zakaria, MB;Belik, AA;Liu, CH;Hsieh, HY;Liao, YT;Malgras, V;Yamauchi, Y;Wu, KC
    贡献者: Institute of Biomedical Engineering and Nanomedicine
    摘要: New nanoporous iron oxide nanoparticles with superparamagnetic behavior were successfully synthesized from Prussian blue (PB) nanocubes through a thermal conversion method and applied to the intracellular drug-delivery systems (DDS) of bladder cancer cells (i.e., T24) with controlled release and magnetic guiding properties. The results of the MTT assay and confocal laser scanning microscopy indicate that the synthesized iron oxide nanoparticles were successfully uptaken by T24 cells with excellent biocompatibility. An anticancer drug, that is, cisplatin, was used as a model drug, and its loading/release behavior was investigated. The intracellular drug delivery efficiency was greatly enhanced for the cisplatin-loaded, PB-derived, magnetic-guided drug-delivery system compared with the non-drug case. The synthesized nanomaterials show great potential as drug vehicles with high biocompatibility, controlled release, and magnetic targeting features for future intracellular DDS.
    日期: 2015-07
    關聯: Chemistry-An Asian Journal. 2015 Jul;10(7):1457-1462.
    Link to: http://dx.doi.org/10.1002/asia.201500232
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1861-4728&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000357206500003
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84934292814
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