本發明揭露一種可抑制細胞生長、提高藥物活性及抑制微生物毒性的表現因子與其篩選方法。本發明亦揭露篩選表現因子抑制劑的方法。本發明所提供之組合物中包含至少一種表現因子抑制劑,且其更可包含至少一種藥物。The invention describes an expression factor and methods for inhibiting the growth of cells, for enhancing the activity of a drug, and for inhibiting the virulence of microbes. Methods of screening for expression factor inhibitors are also described. The compositions comprise at least one expression factor inhibitor and may further comprise at least one drug.