國家衛生研究院 NHRI:Item 3990099045/8918
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    題名: Multi-phase emulsions based on amphiphilic block copolymers
    作者: Huang, MH;Chong, PCS;Leng, CH;Liu, SJ;Chen, HW
    貢獻者: Division of Vaccine Research and Development
    摘要: A method for enhancing a body's response to an immunogen is disclosed. The method comprises immunizing a subject in need thereof a vaccine composition in a water-in-oil (W/O/W) emulsion that comprises (a) an antigen; and (b) an adjuvant composition in a W/O/W emulsion. The adjuvant composition comprises: (i) a continuous aqueous phase comprising H2O; (ii) an oil phase comprising oil dispersed in the continuous aqueous phase, comprising an internal aqueous phase comprising H2O, being dispersed in the oil phase; and a physiologically acceptable lipophilic emulsifier selected from the group consisting of mannide monooleate and sorbitan esters, stabilizing the interface between the inner aqueous phase and the oil phase to form a water-in-oil (W/O) emulsion; and (iii) poly(ethylene glycol)-block-poly(lactide-co-ε-caprolactone), stabilizing the interface between the oil phase and the continuous aqueous phase.
    日期: 2013-05-21
    關聯: US8444993B2/2013-05-21
    Link to: http://v3.espacenet.com/publicationDetails/biblio?CC=US&NR=8444993&KC=B2
    顯示於類別:[黃明熙] 專利
    [莊再成] 專利
    [冷治湘] 專利
    [劉士任] 專利
    [陳信偉] 專利

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