國家衛生研究院 NHRI:Item 3990099045/8923

NHRI > National Institute of Infectious Diseases and Vaccinology > Joe Yen-Hung Chow > Patents > Item 3990099045/8923

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/8923

Title:	多價嵌合型德國麻疹載體病毒疫苗
Other Titles:	Polyvalent chimeric rubella virus-based vaccine
Authors:	Chow, JYH;Sia, CDY;Chong, PCS;Hsiao, KN
Contributors:	Division of Vaccine Research and Development
Abstract:	本發明係關於一種包含德國麻疹病毒(RV)融合基因之嵌合型病毒粒子。該RV融合基因包含第一核苷酸序列，其編碼缺乏RV E1蛋白之RV蛋白，及第二核苷酸序列，其以符合轉譯框架之方式與該第一核苷酸序列連接，且編碼產生體液性免疫的病毒蛋白。該嵌合型病毒粒子不含RV E1蛋白-編碼基因。本發明亦揭示一種生產包含有RV融合基因之嵌合型病毒粒子的病毒包裝細胞，以及包含以符合轉譯框架之方式與啟動子連接之RV融合基因的單離表現載體。A chimeric viral particle that comprises a RV fusion gene is disclosed. The RV fusion gene comprises a first nucleotide sequence encoding a RV that is devoid of RV E1 protein, and a second nucleotide sequence that linked in translation frame to the first nucleotide sequence and encodes a humoral immunogenic viral protein. The chimeric viral particle is free of RV E1 protein-encoding gene. A virus packaging cell that generates the chimeric viral particle comprising a RV fusion gene and an isolated expression vector comprising a RV fusion gene linked in translation frame to a promoter are also disclosed.
Date:	2013-12-21
Relation:	I419968/2013-12-21
Link to:	https://twpat1.tipo.gov.tw/tipotwoc/tipotwkm?!!FR_I419968
Appears in Collections:	[Joe Yen-Hung Chow] Patents [Charles Dwo-Yuan Sia(2006-2014)] Patents [Pele Choi-Sing Chong] Patents

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