本發明係揭露一種奈米粒子容置裝置,奈米安全檢測系統及其方法。此奈米粒子容置裝置包含殼體單元、抽氣單元及負壓控制單元。殼體單元具有一容置空間以容置複數個奈米粒子,且該殼體單元之內壁表面配置一導電薄膜以實現一主動式自潔功能。負壓控制單元控制容置空間之負壓狀態,其中,主動式自潔功能係用以將附著於內側壁面之奈米粒子彈脫至容置空間中,再藉由抽氣單元將奈米粒子抽離該容置空間。A nano-particle containing apparatus, a nano-particle detection system and a method are disclosed. The nano-particle containing apparatus includes a shell, an air pumping device and a negative pressure control system. The shell has a containing space for disposing a plurality of nano-particles. A surface of an inside wall of the shell has an active self-clean function. The negative pressure control system controls the negative pressure status of the containing space. The active self-clean function is that nano-particles adhered to the inside wall are removed into the containing space first. The nano -particles are then discharged by the air pumping device from the containing space.