本發明揭示一種包含非離子性、放射性奈米金粒子(R-GNP)之組成物的製備方法。本發明之方法包含步驟：a)給予一種包含非放射金(Au-197)離子之溶液；及b)將該溶液施予中子照射，以產生一種包含非離子性R-GNP之組成物。或者，本發明之方法包含步驟：a)給予一種包含有非放射金(Au-197)奈米金粒子(GNP)之組成物溶液；及b)將該GNP溶液施予中子照射，以產生一種包含非離子性R-GNP之組成物。本發明亦揭示包含有被封裝於及/或固定附著於MSNs表面之非離子性R-GNP的組成物，及其製造方法。Methods of preparing a composite comprising non-ionic, radioactive gold nanoparticles (R-GNPs) are disclosed. The method comprises: a) providing a solution comprising gold (Au-197) ions; and b) exposing the solution to neutron irradiation to generate a composite comprising non-ionic R-GNPs. Alternatively, the method comprises: a) providing a solution that comprises a composite comprising gold (Au-197) nanoparticles (GNPs); and b) exposing the GNP solution to neutron irradiation to generate a composite comprising non-ionic R-GNPs. Composites that comprise nonionic R-GNPs encapsulated within and/or anchored to MSNs, and methods of making the same are also disclosed.
