本發明提供數種治療神經退化性疾病(neurodegenerative disease)的方法,其係利用篩選適用於神經退化性疾病的化合物來治療疾病。本發明亦提供基因轉殖動物(transgenic animal)以作為神經退化性疾病之研究模型,例如昆蟲。The invention provides methods for treating neurodegenerative disease as well as methods for screening compounds for the treatment of neurodegenerative disease. Transgenic animals, e.g., insects, which may be used as a model for neurodegenerative disease, are also provided.