國家衛生研究院 NHRI:Item 3990099045/9010
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    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/9010


    题名: Indol-3-YL-2-oxoacetamide compounds and methods of use thereof
    作者: Tong, CC;Jen, CS;Chu, HM;Ren, HD;Tai, LW;Chung, LC
    贡献者: Institute of Biotechnology and Pharmaceutical Research
    摘要: The invention is based on the discovery that certain 3-oxoacetamideindolyl compounds have potent anticancer and anti-angiogenic activity. The 3-oxoacetamideindolyl compounds are of the following formula. In this formula, each R1 is independently isoxazolyl, thiazolyl, isothiazolyl, 1, 3, 4-thiadiazolyl, 1, 3-benzothiazolyl, quinolyl, isoquinolyl, thionaphthenyl, or benzofuranyl, each being optionally substituted with 1-6 independent R5; or when taken together with R2 and the nitrogen atom to which they are attached form a 5-8 membered ring comprising C, N, S, or O atoms wherein any atom is optionally substituted with an independent R5. Each R2 is independently H, C1-C10 alkyl, or aryl, each being optionally substituted with 1-4 independent R5; or when taken together with R1 and the nitrogen atom to which they are attached form a 5-8 membered ring comprising C, N, S, or O atoms wherein any atom is optionally substituted with an independent R5. Each R3 is independently C3-C10 cycloalkyl, C4-C10 cycloalkenyl, isoxazolyl, furanyl, thiophenyl, thiazolyl, imidazolyl, pyridyl, or heterocyclyl, each being optionally substituted with 1-4 independent R5. Each R4 is independently H, NO2, halo, CN, R7, OR7, CO2R7, SR7, NR7R 7, C(O)R7, C(O)NR7R7, OC(O)R7, S(O)2R7, S(O)2NR7R7, NR 7C(O)NR7R7, NR7C(O)R7, NR 7(COOR7), NR7S(O)2NR7R7, NR7S(O)2R7, or S(O)2OR7.
    日期: 2005-06-07
    關聯: US6903104B2/2005-06-07
    Link to: http://worldwide.espacenet.com/publicationDetails/biblio?CC=US&NR=6903104&KC=B2
    显示于类别:[陳炯東] 專利
    [陳淑貞(1998-2001)] 專利
    [許明珠(1997-2001)] 專利

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