國家衛生研究院 NHRI:Item 3990099045/9011

NHRI > Institute of Biotechnology and Pharmaceutical Research > Jyh-Haur Chern > Patents > Item 3990099045/9011

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/9011

Title:	Anti-enterovirus compounds
Authors:	Chern, JH;Shia, KS;Shih, SR;Hsu, TA;Tai, CL
Contributors:	Institute of Biotechnology and Pharmaceutical Research
Abstract:	This invention features, among others, a pyrazolopyrimidine compound of formula (A): \| \| A is (CH \| \| 2 \| ) \| q \| --CHR \| a \| R \| b \| ; each of R \| 1 \| and R \| 2 \| , independently, is hydrogen, halogen, cyano, nitro, or alkyl; or R \| 1 \| and R \| 2 \| taken together is (CH \| 2 \| ) \| r \| ; each of R \| 3 \| and R \| 4 \| , independently, is hydrogen, halogen, cyano, nitro, or alkyl; each of R \| 5 \| , R \| a \| , and R \| b \| , independently, is aryl, aralkyl, or heteroaryl, optionally substituted with halogen, cyano, nitro, alkyl, aryl, aralkyl, heteroaryl, OR, O(O)CR, C(O)R, C(O)OR, C(O)NRR', SR, S(O)R, S(O)OR, NRR', NR(O)CR', NRC(O) OR', or NRC(O)NR'R" each of m, n, o, p, and r, independently, is 0 or 1, and q is 0, 1, or 2; in which each of R, R', and R", independently, is hydrogen or alkyl, provided that the sum of m, n, o, and p is 1, 2, 3, or 4. \| This invention features, among others, a pyrazolopyrimidine compound of formula (A):A is (CH2)q-CHR<a>R<b>; each of R1 and R2, independently, is hydrogen, halogen, cyano, nitro, or alkyl; or R1 and R2 taken together is (CH2)r; each of R3 and R4, independently, is hydrogen, halogen, cyano, nitro, or alkyl; each of R5, R<a>, and R<b>, independently, is aryl, aralkyl, or heteroaryl, optionally substituted with halogen, cyano, nitro, alkyl, aryl, aralkyl, heteroaryl, OR, O(O)CR, C(O)R, C(O)OR, C(O)NRR', SR, S(O)R, S(O)OR, NRR', NR(O)CR', NRC(O)OR', or NRC(O)NR'R''; each of m, n, o, p, and r, independently, is 0 or 1, and q is 0, 1, or 2; in which each of R, R', and R'', independently, is hydrogen or alkyl, provided that the sum of m, n, o, and p is 1, 2, 3, or 4.
Date:	2004-11-09
Relation:	US6815444B2/2004-11-09
Link to:	http://worldwide.espacenet.com/publicationDetails/biblio?CC=US&NR=6815444&KC=B2
Appears in Collections:	[Jyh-Haur Chern] Patents [Kak-Shan Shia] Patents [John Tsu-An Hsu] Patents

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