| Abstract: | 一種藉由有效量之乙烯磺酸鹽或乙烯磺醯胺化合物活化PPARγ或抑制NO產生的方法，該化合物具有下列結構式：其中，Ar1為芳香基或雜芳基；R1、R2及R3各自分別為氫、烷基、芳香基、環基、雜芳基或雜環基；X為氧或NR，R為氫、烷基、芳香基、環基、雜芳基或雜環基；以及n為0、1、2、3或4。本發明亦提供一種用於治療NO相關疾病或PPARγ相關疾病之醫藥組成物，該醫藥組成物包含前述之乙烯磺酸鹽或乙烯磺醯胺化合物。 A method for activating PPARγ or inhibiting NO production with an effective amount of a vinylsulfonate or vinylsulfonamide compound of the following formula: wherein Ar1 is aryl or heteroaryl, each of Rl, R2, and R3, independently, is hydrogen, alkyl, aryl, cyclyl, heteroaryl, or heterocyclyl, X is O or NR, R being hydrogen, alkyl, aryl, cyclyl, heteroaryl, or heterocyclyl, and n is 0, 1, 2, 3, or 4. This invention also covers a composition of treating a NO－related disease or PPARγ－related disease which comprises such a vinylsulfonate or vinylsulfonamide compound. |
