本發明係有關於一種式(I)之稠合多環化合物：其中，R’、R”、X、Y、Z、A、B、C、D及n係定義於本文中。本發明亦揭露一種蛋白質激酶(如極光激酶)活性的抑制方法，以及一種以這些化合物治療蛋白質激酶引導的疾病(如癌症)之方法。Fused multicyclic compounds of formula (I):wherein R’, R”, X, Y, Z, A, B, C, D, and n are defined herein. Also disclosed are a method for inhibiting protein kinase (e.g., Aurora kinase) activity and a method for treating a protein kinase mediated disorder (e.g., cancer) with these compounds.
