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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/9147


    Title: ALDH2 polymorphism, associated with attenuating negative symptoms in patients with schizophrenia treated with add-on dextromethorphan
    Authors: Lee, SY;Chen, SL;Chang, YH;Chen, PS;Huang, SY;Tzeng, NS;Wang, LJ;Lee, IH;Wang, TY;Chen, KC;Yang, YK;Hong, JS;Lu, RB
    Contributors: Center for Neuropsychiatric Research
    Abstract: AbstractObjective Increasing the evidence of inflammation’s contribution to schizophrenia; using anti-inflammatory or neurotrophic therapeutic agents to see whether they improve schizophrenia treatment. Dextromethorphan (DM), a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist, might protect monoamine neurons. Whether treating schizophrenia with risperidone plus add-on DM is more effective than risperidone (RISP) alone, and the association between the ALDH2 polymorphism and treatment response were investigated. Methods A double-blind study in which patients with schizophrenia were randomly assigned to the RISP+DM (60 mg/day; n = 74) or the RISP+Placebo (n = 75) group. The Positive and Negative Syndrome Scale (PANSS) and the Scale for the Assessment of Negative Symptoms (SANS) scores were used to evaluate clinical response during weeks 0, 1, 2, 4, 6, 8, and 11. The genotypes of the ALDH2 polymorphism were determined using polymerase chain reactions plus restriction fragment length polymorphism analysis. A generalized estimating equation was used to analyze the effects of ALDH2 polymorphism on the clinical performance of DM. Results PANSS and SANS scores were significantly lower in both groups after 11 weeks of treatment. SANS total scores were significantly lower in the RISP+DM group in patients with the ALDH2*2*2 genotype. Conclusions RISP plus add-on DM treatment reduced negative schizophrenia symptoms in patients with the ALDH2 polymorphism.
    Date: 2015-10
    Relation: Journal of Psychiatric Research. 2015 Oct;69:50-56.
    Link to: http://dx.doi.org/10.1016/j.jpsychires.2015.07.027
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0022-3956&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000361927800008
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84940830961
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