國家衛生研究院 NHRI:Item 3990099045/9151
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    题名: Prenatal exposure to perfluroalkyl substances and children's IQ: The Taiwan maternal and infant cohort study
    作者: Wang, Y;Rogan, WJ;Chen, HY;Chen, PC;Su, PH;Chen, HY;Wang, SL
    贡献者: National Institute of Environmental Health Sciences
    摘要: BACKGROUND: Perfluoroalkyl substances (PFASs) are a group of fluorinated organic substances that are widely used in consumer products and are often detectable in human tissues. Human studies on prenatal exposure to PFASs and neurodevelopment in children are few and inconsistent. METHODS: In the Taiwan Maternal and Infant Cohort Study, we collected serum samples from pregnant women during the third trimester and measured concentrations of 9 PFASs using a high performance liquid chromatography system. A subsample of their children was assessed with full scale intelligence quotient (FSIQ), verbal IQ (VIQ) and performance IQ (PIQ) at both age 5 (n=120) and 8 years (n=120). We used multivariate linear regression models to examine prenatal PFAS exposure in relation to IQ scores at each age period. RESULTS: Prenatal perfluoroundecanoic acid (PFUnDA) concentrations were inversely associated with children's PIQ scores at age 5 years, with an adjusted coefficient (beta) of -1.6 (95% confidence interval [CI]: (-3.0, -0.2). When children reached 8 years, most of the prenatal PFASs showed inverse association with children's FSIQ, VIQ and PIQ scores. Among them, prenatal perfluorononanoic acid (PFNA) reached significance. Children with higher prenatal PFNA levels had lower VIQ with an adjusted beta of -2.1 (95% CI: -3.9, -0.2). CONCLUSIONS: We found two prenatal PFAS exposure, both long-chain PFASs, in association with decreased IQ test scores in children. Our findings suggest more studies on long-chain PFASs and children's neurodevelopment.
    日期: 2015-10
    關聯: International Journal of Hygiene and Environmental Health. 2015 Oct;218(7):639-644.
    Link to: http://dx.doi.org/10.1016/j.ijheh.2015.07.002
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1438-4639&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000375731300006
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84940597715
    显示于类别:[王淑麗] 期刊論文

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