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Please use this identifier to cite or link to this item:
http://ir.nhri.org.tw/handle/3990099045/9178
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| Title: | Evaluation of X-ray fuorescence emission tomography for real-time assessment of photodynamic therapy effect |
| Authors: | George, J;Groll, A;Cheng, SH;Chen, CT;La Riviere, P;Lo, LW;Souris, J;Meng, LJ |
| Contributors: | Institute of Biomedical Engineering and Nanomedicine |
| Abstract: | Objectives This work studies the use of x-ray fluorescence emission tomography (XFET) for assessing the therapeutic effect of x-ray induced photodynamic therapy (XPDT) in real-time. XPDT, as compared to optically induced PDT, has greater tissue penetration to precisely induce the PDT effect in nanoparticles (NP’s)—containing heavy elements such as yttrium and hafnium—within a deeply embedded tumor [1]-[5]. XFET could determine the distribution of the NPs for a radiation treatment plan and then, during therapy delivery, assess the therapeutic effect indirectly by measuring the fluorescent x-rays emitted by the NPs. As a feasibility study, an existing XFET system will stimulate and image yttrium and hafnium NPs loaded in a small superficial region of a mouse phantom to model melanoma.Methods The XFET setup uses a benchtop monochromatic x-ray source to focus 17.4 keV x-rays to a pencil beam of 100 μm diameter to the sample. A direct-detection CCD camera (DO-936N), which is coupled to an aperture with its slit oriented perpendicular to the beam, collects the fluorescence from a precisely known origin constrained by this geometry. By scanning the phantom across the beam, a 3D image can be built line-by-line with a spatial resolution of 100 μm, which is determined by the beam diameter and slit width.Results In prelimary work, this method produced images of an osmium-loaded zebrafish and a phantom of bromide, osmium, and iron. Further studies will image the mouse phantom with yttrium and hafnium NPs loaded into superficial regions. The presentation will show the resultant 3D images.Conclusions The results from the phantom model of superficial melanoma will help demonstrate the feasibility of using XFET to image PDT NPs containing high-Z elements, and will provide groundwork for the precise real-time assessment of the XPDT effect in deeper tissue. |
| Date: | 2015-05 |
| Relation: | Journal of Nuclear Medicine. 2015 May;56(Suppl. 3):100. |
| Link to: | http://jnm.snmjournals.org/content/56/supplement_3/100.short |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0161-5505&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:000358738800101 |
| Appears in Collections: | [羅履維] 會議論文/會議摘要
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| ISI000358738800101.pdf | | 54Kb | Adobe PDF | 487 | View/Open |
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