國家衛生研究院 NHRI:Item 3990099045/9185
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/9185


    Title: Association of prescribed Chinese herbal medicine use with risk of end-stage renal disease in patients with chronic kidney disease
    Authors: Lin, MY;Chiu, YW;Chang, JS;Lin, HL;Lee, CT;Chiu, GF;Kuo, MC;Wu, MT;Chen, HC;Hwang, SJ
    Contributors: Division of Geriatric Research
    Abstract: The evidence on whether Chinese herbal medicines affect outcome in patients with chronic kidney disease (CKD) is limited. Here we retrospectively explored the association of prescribed Chinese herbal medicine use and the risk of end-stage renal disease (ESRD) in patients with CKD. Patients with newly diagnosed CKD in the Taiwan National Health Insurance Research Database from 2000 to 2005 were categorized into new use or nonuse of prescribed Chinese herbal medicine groups. These patients were followed until death, dialysis initiation, or till the end of 2008. Among the 24,971 study patients, 11,351 were new users of prescribed Chinese herbal medicine after CKD diagnosis. Overall, after adjustment for confounding variables, the use group exhibited a significant 60% reduced ESRD risk (cause-specific hazard ratio 0.41, 95% confidence interval 0.37-0.46) compared with the nonuse group. The change was significantly large among patients using wind dampness-dispelling formulas (0.63, 0.51-0.77) or harmonizing formulas (0.59, 0.46-0.74), suggesting an independent association between specific Chinese herbal medicines and reduced ESRD risk. The findings were confirmed using propensity score matching, stratified analyses, and three weighting methods. However, dampness-dispelling and purgative formulas were associated with increased ESRD risk. Thus, specific Chinese herbal medicines are associated with reduced or enhanced ESRD risk in patients with CKD.
    Date: 2015-12
    Relation: Kidney International. 2015 Dec;88(6):1365-1373.
    Link to: http://dx.doi.org/10.1038/ki.2015.226
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0085-2538&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000366395300022
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84951569700
    Appears in Collections:[Others] Periodical Articles

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