Siblings Conference Papers/Meeting Abstract [10/19] Papers [0/1] Patents [0/82] Collection Statistics Item counts issued in 3 years:1(0.91%) Items With Fulltext:110(100.00%) Download counts of the item Download times greater than 0:110(100.00%) Download times greater than 100:110(100.00%) Total Bitstream Download Counts:92310(93.25%) Last Update: 2024-11-28 17:52 Top Upload Loading... Top Download Loading... Recent Submissions Selective and antagonist-dependent ... DBPR108, a novel dipeptidyl peptida... BPRDP056, a novel small molecule dr... The in vivo antinociceptive and mu-... A novel, potent, and orally bioavai... 4-Bromophenylhydrazinyl benzenesulf... Identification of an oxime-containi... Targeting coronaviral replication a... A potent, selective, and orally bio... N-Indolylglycosides bearing modific...

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Showing items 1-25 of 110. (5 Page(s) Totally) 1 2 3 4 5 > >> View [10|25|50] records per page

Date	Title	Relation
2022-11	Selective and antagonist-dependent µ-opioid receptor activation by the combination of 2-{[2-(6-chloro-3,4-dihydro-1(2H)-quinolinyl)-2-oxoethyl]sulfanyl}-5-phenyl-4,6-(1H,5H)-pyrimidinedione and naloxone/naltrexone	Bioorganic Chemistry. 2022 Nov;128:Article number 105905.
2021-08-01	DBPR108, a novel dipeptidyl peptidase-4 inhibitor with antihyperglycemic activity	Life Sciences. 2021 Aug 1;278:Article number 119574.
2021-01	BPRDP056, a novel small molecule drug conjugate specifically targeting phosphatidylserine for cancer therapy	Translational Oncology. 2021 Jan;14(1):Article number 100897.
2019-04-01	A novel, potent, and orally bioavailable thiazole HCV NS5A inhibitor for the treatment of hepatitis C virus	European Journal of Medicinal Chemistry. 2019 Apr 1;167:245-268.
2019-04-01	The in vivo antinociceptive and mu-opioid receptor activating effects of the combination of N-phenyl-2′,4′-dimethyl-4,5′-bi-1,3-thiazol-2-amines and naloxone	European Journal of Medicinal Chemistry. 2019 Apr 1;167:312-323.
2019-03	Synthesis and biological evaluation of N-glucosyl indole derivatives as sodium-dependent glucose co-transporter 2 inhibitors	Bioorganic Chemistry. 2019 Mar;83:520-525.
2018-04	4-Bromophenylhydrazinyl benzenesulfonylphenylureas as indoleamine 2,3-dioxygenase inhibitors with in vivo target inhibition and anti-tumor efficacy	Bioorganic Chemistry. 2018 Apr;77:600-607.
2018-01-01	Identification of an oxime-containing C-glucosylarene as a potential inhibitor of sodium-dependent glucose co-transporter 2	European Journal of Medicinal Chemistry. 2018 Jan 1;143:611-620.
2017-06-22	Targeting coronaviral replication and cellular JAK2 mediated dominant NF-kappaB activation for comprehensive and ultimate inhibition of coronaviral activity	Scientific Reports. 2017 Jun 22;7:Article number 4105.
2017-01	A potent, selective, and orally bioavailable HCV NS5A inhibitor for treatment of Hepatitis C Virus: (S)-1-((R)-2-(Cyclopropanecarboxamido)-2-phenylacetyl)-N-(4-phenylthiazo l-2-yl)pyrrolidine-2-carboxamide	Journal of Medicinal Chemistry. 2017 Jan;60(1):228-247.
2016-05	N-Indolylglycosides bearing modifications at the glucose C6-Position as Sodium-Dependent Glucose Co-transporter 2 inhibitors	Bioorganic and Medicinal Chemistry. 2016 May;24(10):2242-2250.
2016-01	Phenyl benzenesulfonylhydrazides exhibit selective Indoleamine 2,3-Dioxygenase inhibition with potent in vivo pharmacodynamic activity and antitumor efficacy	Journal of Medicinal Chemistry. 2016 Jan;59(1):419-430.
2015-07	Development and application of a fluorescent glucose uptake assay for the high-throughput screening of non-glycoside SGLT2 inhibitors	European Journal of Pharmaceutical Sciences. 2015 Jul;74:40-44.
2015-07	Pharmacological induction of human fetal globin gene in hydroxyurea-resistant primary adult erythroid cells	Molecular and Cellular Biology. 2015 Jul;35(14):2541-2553.
2015-07	Identification of a potent 5-phenyl-thiazol-2-ylamine-based inhibitor of FLT3 with activity against drug resistance-conferring point mutations	European Journal of Medicinal Chemistry. 2015 Jul;100:151-161.
2015-05	A novel peripheral cannabinoid receptor 1 antagonist, BPR0912, reduces weight independently of food intake and modulates thermogenesis	Diabetes, Obesity and Metabolism. 2015 May;17(5):495-504.
2014-12-01	Morphine drives internal ribosome entry site-mediated hnRNP K translation in neurons through opioid receptor-dependent signaling	Nucleic Acids Research. 2014 Dec 1;42(21):13012-13025.
2014-09	Discovery, structure-activity relationship studies, and anti-nociceptive effects of 1-phenyl-3,6,6-trimethyl-1,5,6,7-tetrahydro-4H-indazol-4-one as novel opioid receptor agonists	Bioorganic and Medicinal Chemistry. 2014 Sep;22(17): 4694-4703.
2014-08	Discovery and structure-activity relationships of phenyl benzenesulfonylhydrazides as novel indoleamine 2,3-dioxygenase inhibitors	Bioorganic and Medicinal Chemistry Letters. 2014 Aug;24(15):3403-3406.
2014-08	Discovery of selective inhibitors of Glutaminase-2, which inhibit mTORC1, activate autophagy and inhibit proliferation in cancer cells	Oncotarget. 2014 Aug;5(15):6087-6101.
2014-01-08	Evaluation of the antitumor effects of BPR1J-340, a potent and selective FLT3 inhibitor, alone or in combination with an HDAC inhibitor, vorinostat, in AML cancer	PLoS ONE. 2014 Jan 8;9(1):Article number e83160.
2013-11-13	Discovery of 1-(2,4-Dichlorophenyl)-N-(piperidin-1-yl)-4-((pyrrolidine-1-sulfonamido)methyl)-5 -(5-((4-(trifluoromethyl)phenyl)ethynyl)thiophene-2-yl)-1H-pyrazole-3-carboxamide as a novel peripherally restricted cannabinoid-1 receptor antagonist with significant weight-loss efficacy in diet-induced obese mice	Journal of Medicinal Chemistry. 2013 Nov 13;56(24):9920-9933.
2013-11	BPR0C305, an orally active microtubule-disrupting anticancer agent	Anticancer Drugs. 2013 Nov;24(10):1047-1057.
2013-06-28	Optimization of ligand and lipophilic efficiency to identify an in vivo active furano-pyrimidine aurora kinase inhibitor	Journal of Medicinal Chemistry. 2013 Jun 28;56(13):5247-5260.
2013-06	c-Jun-mediated anti-cancer mechanisms of tylophorine	Carcinogenesis. 2013 Jun;34(6):1304-1314.

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