國家衛生研究院 NHRI:Item 3990099045/9310

NHRI > Institute of Biomedical Engineering and Nanomedicine > Kurt Ming-Chao Lin > Periodical Articles > Item 3990099045/9310

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Title:	Neonatal death and heart failure in mouse with transgenic HSP60 expression
Authors:	Chen, TH;Liu, SW;Chen, MR;Cho, KH;Chen, TY;Chu, PH;Kao, YY;Hsu, CH;Lin, KM
Contributors:	Institute of Biomedical Engineering and Nanomedicine
Abstract:	Mitochondrial heat shock proteins, such as HSP60, are chaperones responsible for the folding, transport, and quality control of mitochondrial matrix proteins and are essential for maintaining life. Both prosurvival and proapoptotic roles have been proposed for HSP60, and HSP60 is reportedly involved in the initiation of autoimmune, metabolic, and cardiovascular diseases. The role of HSP60 in pathogenesis of these diseases remains unclear, partly because of the lack of mouse models expressing HSP60. In this study we generated HSP60 conditional transgenic mice suitable for investigating in vivo outcomes by expressing HSP60 at the targeted organ in disease models. Ubiquitous HSP60 induction in the embryonic stage caused neonatal death in mice at postnatal day 1. A high incidence of atrial septal defects was observed in HSP60-expressing mice, with increased apoptosis and myocyte degeneration that possibly contributed to massive hemorrhage and sponge-like cardiac muscles. Our results showed that neonatal heart failure through HSP60 induction likely involves developmental defects and excessive apoptosis. The conditional HSP60 mouse model is useful for studying crucial biological questions concerning HSP60.
Date:	2015-10
Relation:	BioMed Research International. 2015 Oct;2015:Article number 539805.
Link to:	http://dx.doi.org/10.1155/2015/539805
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000363150000001
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84945305033
Appears in Collections:	[Kurt Ming-Chao Lin] Periodical Articles

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