國家衛生研究院 NHRI:Item 3990099045/9314
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    題名: SeqSIMLA2_exact: Simulate multiple disease sites in large pedigrees with given disease status for diseases with low prevalence
    作者: Yao, PJ;Chung, RH
    貢獻者: Division of Biostatistics and Bioinformatics
    摘要: It is difficult for current simulation tools to simulate se-quence data in a pre-specified pedigree structure and pre-specified affection status. Previously, we developed a flexible tool, SeqSIMLA2, for simulating sequence data in either unrelated case-control or family samples with different disease and quantitative trait models. Here we extended the tool to efficiently simulate sequences with multiple disease sites in large pedigrees with a given disease status for each pedigree member, assuming that the disease prevalence is low.
    日期: 2016-02
    關聯: Bioinformatics. 2016 Feb;32(4):557-562.
    Link to: http://dx.doi.org/10.1093/bioinformatics/btv626
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1367-4803&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000371693700011
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84959935167
    顯示於類別:[鍾仁華] 期刊論文

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