國家衛生研究院 NHRI:Item 3990099045/9315
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    題名: Tylophorine compounds exert anti-cancer activity by targeting a ribonucleoprotein complex containing caprin-1 and c-Myc mRNA
    作者: Qiu, YQ;Yang, CW;Lee, YZ;Yang, RB;Lee, CH;Hsu, HY;Chang, CC;Lee, SJ
    貢獻者: Institute of Biotechnology and Pharmaceutical Research
    摘要: Tylophorine and its derivatives exhibit anti-cancer activities, but their cellular targets remain to be elucidated. We used a biotinylated tylophorine derivative to probe for the interacting cellular target(s) of tylophorine. Tylophorine targets and sequesters caprin-1, G3BP1, c-Myc mRNA and cyclin D1/D2 mRNA-associated ribonucleoprotein complexes to the polysomal fractions, thereby repressing the protein expression of the associated mRNA-transcripts. Gene expression profiling and gain-of-c-Myc-function experiments in tylophorine-treated carcinoma cells revealed that the down-regulation of c-Myc contributes to the anti-oncogenic effects of tylophorine. Furthermore, the potent tylophorine derivative dibenzoquinoline-33b elicited a similar effect, as c-Myc protein levels were also decreased in xenograft tumors treated with dibenzoquinoline-33b.Thus, tylophorine compounds exert anti-cancer activity predominantly by targeting and sequestering the caprin-1 protein and c-Myc mRNA associated ribonucleoprotein complex.
    日期: 2015-04
    關聯: FASEB Journal. 2015 Apr;29(1, Suppl.):Abstract number LB132
    Link to: http://www.fasebj.org/content/29/1_Supplement/LB132.short
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0892-6638&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000361470500131
    顯示於類別:[李秀珠] 會議論文/會議摘要

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